CCN5 (WISP2) Gene
CCN Family Member 5, a matricellular protein involved in cell growth, differentiation, and tumor suppression
Gene Information Card
| Symbol | CCN5 |
|---|---|
| Full Name | Cellular Communication Network Factor 5 |
| Gene Type | protein-coding |
| Chromosomal Location | 20q13.12 |
| NCBI Gene ID | 8846 ncbi.nlm.nih.gov/gene/8846 |
| Ensembl ID | ENSG00000101210 |
| UniProt ID | O76076 |
| OMIM ID | 603399 |
| HGNC ID | 12771 |
| Aliases | WISP2, CT58, CTGF-L, WISP-2 |
Description
CCN5 (Cellular Communication Network Factor 5), also known as WISP2, is a member of the CCN family of matricellular proteins. It is involved in regulating cell proliferation, adhesion, migration, and differentiation. CCN5 is frequently downregulated in various cancers and acts as a tumor suppressor by inhibiting Wnt signaling and promoting apoptosis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast Cancer | CCN5 downregulation promotes epithelial-mesenchymal transition and metastasis | PMID: 23431173 |
| Colorectal Cancer | Loss of CCN5 expression correlates with poor prognosis and increased invasion | PMID: 21947069 |
| Pancreatic Cancer | CCN5 inhibits tumor growth and angiogenesis via suppression of Wnt/β-catenin signaling | PMID: 24316972 |
| Osteoarthritis | CCN5 modulates chondrocyte differentiation and matrix remodeling | PMID: 25667113 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Heart | 0.8 | Low |
| Adipose Tissue | 12.5 | Medium |
| Breast | 4.2 | Low |
| Colon | 1.1 | Low |
| Pancreas | 0.6 | Low |
| Liver | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 0.5 | Low expression |
| MDA-MB-231 (breast cancer) | 0.1 | Very low expression |
| HCT116 (colorectal cancer) | 0.3 | Low expression |
| PANC-1 (pancreatic cancer) | 0.2 | Low expression |
| HEK293 (embryonic kidney) | 1.2 | Moderate expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.1% | Unknown |
| c.202C>T | missense | <0.1% | Unknown |
| c.346G>A | missense | <0.1% | Unknown |
Mutation functional classification
Loss of Function (LOF)
Frequent downregulation or loss of expression in cancers; no common loss-of-function mutations reported.
Gain of Function (GOF)
Not reported.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Wnt signaling pathway
• TGF-beta signaling pathway
• CCN family signaling
Protein Summary
CCN5 is a 29 kDa secreted matricellular protein composed of four conserved domains: IGFBP, VWC, TSP1, and CT. It modulates cell-matrix interactions and growth factor signaling. CCN5 is considered a tumor suppressor due to its ability to inhibit Wnt/β-catenin signaling and induce apoptosis in cancer cells.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCN5 Knockout HEK293 Cell Line | EDJ-KQ2917 | Human | 8839 | Details Get a Quote |
| CCN5 Knockout A-549 Cell Line | EDJ-KQ24012 | Human | 8839 | Details Get a Quote |
| CCN5 Knockout HeLa Cell Line | EDJ-KQ24013 | Human | 8839 | Details Get a Quote |
| CCN5 Knockout HCT 116 Cell Line | EDJ-KQ71969 | Human | 8839 | Details Get a Quote |
