CCN3 (Cellular Communication Network Factor 3)
A matricellular protein involved in angiogenesis, fibrosis, and tumorigenesis
Gene Information Card
| Symbol | CCN3 |
|---|---|
| Full Name | Cellular Communication Network Factor 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 8q24.12 |
| NCBI Gene ID | 4856 ncbi.nlm.nih.gov/gene/4856 |
| Ensembl ID | ENSG00000136936 |
| UniProt ID | P48745 |
| OMIM ID | 164958 |
| HGNC ID | 7880 |
| Aliases | NOV, IGFBP9, NOVH, CCN3 |
Description
CCN3 (Cellular Communication Network Factor 3), also known as NOV (nephroblastoma overexpressed), is a member of the CCN family of matricellular proteins. It plays a role in cell adhesion, migration, proliferation, differentiation, and angiogenesis. CCN3 is involved in development, wound healing, fibrosis, and tumorigenesis. It interacts with integrins, Notch, and other signaling pathways.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Nephroblastoma (Wilms tumor) | Overexpression of CCN3 in nephroblastoma suggests a role in tumor growth and differentiation. | PMID: 1379230 |
| Fibrotic diseases (e.g., systemic sclerosis) | CCN3 is upregulated in fibrotic tissues and modulates TGF-β signaling, promoting extracellular matrix deposition. | PMID: 21300908 |
| Breast cancer | CCN3 expression is altered in breast cancer; it can act as a tumor suppressor or oncogene depending on context. | PMID: 15604212 |
| Prostate cancer | CCN3 is downregulated in prostate cancer and may inhibit tumor progression. | PMID: 16951123 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 0.8 | Low |
| Brain | 1.2 | Low |
| Breast | 2.5 | Medium |
| Colon | 1.0 | Low |
| Heart | 0.5 | Low |
| Kidney | 3.0 | Medium |
| Liver | 0.6 | Low |
| Lung | 1.8 | Low |
| Ovary | 2.0 | Medium |
| Pancreas | 0.9 | Low |
| Placenta | 4.5 | High |
| Prostate | 1.5 | Low |
| Skin | 2.2 | Medium |
| Spleen | 0.7 | Low |
| Testis | 3.5 | High |
| Thyroid | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HUVEC (endothelial) | 3.8 | High expression in endothelial cells |
| MCF7 (breast cancer) | 2.1 | Moderate expression |
| HEK293 (embryonic kidney) | 4.0 | High expression |
| A549 (lung cancer) | 1.5 | Low expression |
| HepG2 (liver cancer) | 0.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | Rare | Unknown functional effect |
| c.202G>A (p.Gly68Arg) | Missense | Rare | Unknown functional effect |
| c.350_351insA | Frameshift | Rare | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.350_351insA) likely lead to truncated protein and loss of function.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in CCN3.
Dominant Negative (DN)
No dominant-negative mutations described for CCN3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Integrin signaling pathway
• Notch signaling pathway
• TGF-β signaling pathway
• Wnt signaling pathway
• PI3K-Akt signaling pathway
Protein Summary
CCN3 is a secreted matricellular protein of 357 amino acids (UniProt P48745). It contains four conserved domains: IGFBP, VWC, TSP1, and CT. The protein modulates cell-matrix interactions and signaling via integrins, Notch, and other receptors. It is involved in angiogenesis, fibrosis, and tumor suppression or promotion depending on cellular context.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCN3 Knockout HEK293 Cell Line | EDJ-KQ1538 | Human | 4856 | Details Get a Quote |
| CCN3 Knockout HCT 116 Cell Line | EDJ-KQ22511 | Human | 4856 | Details Get a Quote |
| CCN3 Knockout HeLa Cell Line | EDJ-KQ22512 | Human | 4856 | Details Get a Quote |
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