CCL7: C-C Motif Chemokine Ligand 7
A key chemokine involved in inflammation, immune cell recruitment, and tumor progression.
Gene Information Card
| Symbol | CCL7 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 7 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 6354 ncbi.nlm.nih.gov/gene/6354 |
| Ensembl ID | ENSG00000108688 |
| UniProt ID | P80098 |
| OMIM ID | 158281 |
| HGNC ID | 10634 |
| Aliases | MCP-3, MCP3, SCYA6, SCYA7 |
Description
CCL7 (C-C Motif Chemokine Ligand 7) is a small cytokine belonging to the CC chemokine family. It is produced by various cell types including monocytes, fibroblasts, and endothelial cells. CCL7 binds to chemokine receptors such as CCR1, CCR2, and CCR3, mediating the recruitment of monocytes, macrophages, T cells, and eosinophils to sites of inflammation. It plays roles in immune surveillance, inflammatory diseases, and tumor microenvironment modulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | CCL7 promotes monocyte and macrophage infiltration into synovial tissue, contributing to joint inflammation and destruction. | Increased CCL7 levels found in synovial fluid and serum of RA patients (PMID: 10935631) |
| Atherosclerosis | CCL7 recruits monocytes to arterial walls, promoting foam cell formation and plaque development. | CCL7 expression elevated in atherosclerotic lesions (PMID: 11823457) |
| Breast Cancer | CCL7 secreted by tumor cells attracts macrophages and T cells, influencing tumor progression and metastasis. | High CCL7 expression correlates with poor prognosis in breast cancer (PMID: 22952447) |
| Asthma | CCL7 recruits eosinophils and Th2 cells to airways, contributing to airway inflammation and hyperresponsiveness. | Elevated CCL7 levels in bronchoalveolar lavage fluid of asthmatics (PMID: 10493732) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Bone Marrow | 6.1 | Low |
| Thymus | 4.7 | Low |
| Small Intestine | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 45.2 | High expression after LPS stimulation |
| HUVEC (endothelial) | 22.8 | Constitutive expression |
| A549 (lung carcinoma) | 8.5 | Moderate expression |
| MCF-7 (breast cancer) | 3.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.275C>T (p.Pro92Leu) | Missense | Rare (<0.01%) | Unknown functional impact |
| c.1A>G (p.Met1Val) | Start loss | Rare | Likely loss of function |
Mutation functional classification
Loss of Function (LOF)
Start loss mutations (e.g., p.Met1Val) are predicted to abolish protein translation.
Gain of Function (GOF)
No gain-of-function mutations reported in CCL7.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • chemokine-mediated signaling pathway (GO:0070098) |
| • extracellular space (GO:0005615) |
Pathways
• Chemokine signaling pathway (KEGG hsa04062)
• Cytokine-cytokine receptor interaction (KEGG hsa04060)
• Toll-like receptor signaling pathway (KEGG hsa04620)
Protein Summary
CCL7 is a 99-amino-acid secreted chemokine (precursor) that is processed to a mature form of 76 amino acids. It contains four conserved cysteine residues forming two disulfide bonds characteristic of CC chemokines. The protein binds to G-protein-coupled receptors CCR1, CCR2, and CCR3, inducing intracellular calcium flux and integrin activation. CCL7 is involved in monocyte and eosinophil chemotaxis, and its dysregulation is linked to inflammatory diseases and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL7 Knockout HEK293 Cell Line | EDJ-KQ50614 | Human | 6354 | Details Get a Quote |
| CCL7 Knockout HeLa Cell Line | EDJ-KQ54416 | Human | 6354 | Details Get a Quote |
| CCL7 Knockout A-549 Cell Line | EDJ-KQ62905 | Human | 6354 | Details Get a Quote |
| CCL7 Knockout HCT 116 Cell Line | EDJ-KQ71373 | Human | 6354 | Details Get a Quote |
