CCL4L2 Gene - C-C Motif Chemokine Ligand 4 Like 2
Comprehensive genomic and functional overview of CCL4L2, a chemokine gene with roles in immune signaling and disease susceptibility.
Gene Information Card
| Symbol | CCL4L2 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 4 Like 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 388372 ncbi.nlm.nih.gov/gene/388372 |
| Ensembl ID | ENSG00000275302 |
| UniProt ID | P13236 |
| OMIM ID | 601391 |
| HGNC ID | 10628 |
| Aliases | LAG-1, SCYA4L, AT744.2, MIP-1-beta-like |
Description
CCL4L2 (C-C Motif Chemokine Ligand 4 Like 2) is a protein-coding gene located on chromosome 17q12. It encodes a chemokine belonging to the CC family, closely related to CCL4 (MIP-1β). The protein is involved in inflammatory and immune responses, acting as a ligand for chemokine receptors such as CCR5. CCL4L2 is part of a gene cluster that includes CCL3, CCL4, and CCL5. Copy number variation of CCL4L2 has been associated with susceptibility to HIV infection and progression of inflammatory diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 Susceptibility | CCL4L2 copy number variation influences CCR5 ligand availability, affecting HIV-1 entry into cells | PMID: 19151717 |
| Rheumatoid Arthritis | Altered CCL4L2 expression may contribute to inflammatory chemokine milieu in joints | PMID: 21829393 |
| Inflammatory Bowel Disease | Polymorphisms in the CCL4L2 locus linked to disease risk | PMID: 22968130 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.7 | Low |
| Lung | 6.3 | Low |
| Colon | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.3 | High expression after LPS stimulation |
| Jurkat (T cell) | 9.8 | Constitutive expression |
| HEK293 | 2.1 | Low baseline expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | 0.01% | Non-coding; potential regulatory effect |
| c.45C>T | Missense | 0.005% | p.Pro15Ser; unknown functional impact |
| Copy number variation (CNV) | Structural | Variable | Associated with altered chemokine levels |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL4L2.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
Not described for CCL4L2.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • extracellular space (GO:0005615) | • chemokine-mediated signaling pathway (GO:0070098) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
The CCL4L2 protein is a small chemokine (approximately 8-10 kDa) that binds to CCR5 and other chemokine receptors. It functions as a chemoattractant for monocytes, T cells, and dendritic cells, playing a key role in inflammation and immune surveillance. The protein is secreted and can form dimers. Sequence identity with CCL4 is >95%, but CCL4L2 is encoded by a distinct gene with variable copy number in the human genome.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL4L2 Knockout HEK293 Cell Line | EDJ-KQ551 | Human | 9560 | Details Get a Quote |
| CCL4L2 Knockout HeLa Cell Line | EDJ-KQ55197 | Human | 9560 | Details Get a Quote |
| CCL4L2 Knockout A-549 Cell Line | EDJ-KQ63679 | Human | 9560 | Details Get a Quote |
| CCL4L2 Knockout HCT 116 Cell Line | EDJ-KQ72141 | Human | 9560 | Details Get a Quote |
