CCL4L1 Gene - C-C Motif Chemokine Ligand 4 Like 1
Chemokine gene involved in immune regulation and inflammatory response
Gene Information Card
| Symbol | CCL4L1 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 4 Like 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 9560 ncbi.nlm.nih.gov/gene/9560 |
| Ensembl ID | ENSG00000275302 |
| UniProt ID | P13236 |
| OMIM ID | 601391 |
| HGNC ID | 10628 |
| Aliases | LAG-1, SCYA4L1, MIP-1β, ACT-2 |
Description
CCL4L1 (C-C Motif Chemokine Ligand 4 Like 1) is a protein-coding gene that belongs to the CC chemokine family. It encodes a cytokine that functions as a chemoattractant for natural killer cells, monocytes, and other immune cells. The protein binds to chemokine receptors CCR5 and CCR8, playing a role in inflammatory responses and HIV infection susceptibility. CCL4L1 is highly similar to CCL4 and is located in a gene cluster on chromosome 17q12.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 Infection | CCL4L1 encodes a ligand for CCR5, a coreceptor for HIV-1 entry; copy number variation influences susceptibility | OMIM 601391; NCBI Gene |
| Inflammatory Diseases | Overexpression associated with chronic inflammation and autoimmune conditions | NCBI Gene; UniProt |
| Cancer | Altered expression in certain tumors; potential role in tumor immune evasion | COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.7 | Medium |
| Lung | 3.1 | Low |
| Liver | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.3 | High expression after stimulation |
| Jurkat (T-cell) | 9.8 | Moderate expression |
| HeLa (cervical) | 2.1 | Low expression |
| HEK293 (embryonic kidney) | 1.0 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional effect |
| c.274C>T | synonymous | <0.01% | No known effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL4L1.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • chemokine-mediated signaling pathway (GO:0070098) |
| • extracellular space (GO:0005615) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
CCL4L1 encodes a 92-amino acid protein (UniProt P13236) that is a member of the CC chemokine family. The mature secreted protein (69 amino acids after signal peptide cleavage) acts as a chemoattractant for monocytes, NK cells, and T lymphocytes. It binds to CCR5 and CCR8 receptors, inducing calcium flux and cell migration. CCL4L1 is involved in inflammatory responses and is a natural ligand for the HIV-1 coreceptor CCR5, with copy number variation affecting HIV susceptibility.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL4L1 Knockout HEK293 Cell Line | EDJ-KQ12816 | Human | 388372 | Details Get a Quote |
| CCL4L1 Knockout A-549 Cell Line | EDJ-KQ41950 | Human | 388372 | Details Get a Quote |
| CCL4L1 Knockout HCT 116 Cell Line | EDJ-KQ41951 | Human | 388372 | Details Get a Quote |
| CCL4L1 Knockout HeLa Cell Line | EDJ-KQ41952 | Human | 388372 | Details Get a Quote |
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