CCL3L3 Gene - C-C Motif Chemokine Ligand 3 Like 3
Comprehensive genomic and functional analysis of CCL3L3, a chemokine gene with implications in immune response and disease susceptibility.
Gene Information Card
| Symbol | CCL3L3 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 3 Like 3 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 414062 ncbi.nlm.nih.gov/gene/414062 |
| Ensembl ID | ENSG00000276085 |
| UniProt ID | P16619 |
| OMIM ID | 601395 |
| HGNC ID | 10627 |
| Aliases | CCL3L1, LD78, MIP-1alpha, SCYA3L1 |
Description
CCL3L3 (C-C Motif Chemokine Ligand 3 Like 3) is a protein-coding gene located on chromosome 17q12. It encodes a member of the CC chemokine family, which is involved in inflammatory and immune responses. The protein is a ligand for CCR5 and CCR1 receptors and plays a role in chemotaxis, particularly of monocytes and T cells. CCL3L3 is highly similar to CCL3L1 and is part of a copy number variable region associated with susceptibility to HIV infection and other inflammatory conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 Susceptibility | CCL3L3 copy number variation influences CCR5 ligand levels, affecting HIV-1 entry and disease progression. | PMID: 15791265, OMIM 601395 |
| Autoimmune Diseases | Altered CCL3L3 expression may contribute to inflammatory responses in rheumatoid arthritis and multiple sclerosis. | PMID: 17928401 |
| Cancer | Dysregulation of CCL3L3 in tumor microenvironment may promote metastasis via chemokine signaling. | PMID: 22952447 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph Node | 0.5 | Low |
| Spleen | 0.3 | Low |
| Bone Marrow | 0.2 | Low |
| Lung | 0.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 0.8 | Low expression |
| Jurkat (T cell) | 0.4 | Low expression |
| HeLa (cervical) | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | SNV | <0.01% | Non-coding, uncertain significance |
| c.45C>T | Missense | <0.01% | p.Pro15Ser, likely benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • chemokine-mediated signaling pathway (GO:0070098) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
The CCL3L3 protein (UniProt P16619) is a secreted chemokine of approximately 8 kDa (92 amino acids). It belongs to the CC chemokine family and binds to CCR1 and CCR5 receptors. It functions as a chemoattractant for monocytes, T cells, and natural killer cells, playing a key role in inflammation and antiviral immunity. The protein is highly similar to CCL3 (MIP-1alpha) and is encoded by a gene within a segmental duplication on chromosome 17q12.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL3L3 Knockout HEK293 Cell Line | EDJ-KQ12815 | Human | 414062 | Details Get a Quote |
| CCL3L3 Knockout HeLa Cell Line | EDJ-KQ60356 | Human | 414062 | Details Get a Quote |
| CCL3L3 Knockout A-549 Cell Line | EDJ-KQ68824 | Human | 414062 | Details Get a Quote |
| CCL3L3 Knockout HCT 116 Cell Line | EDJ-KQ77188 | Human | 414062 | Details Get a Quote |
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