CCL28: Chemokine (C-C Motif) Ligand 28
A key mucosal chemokine involved in immune cell trafficking, angiogenesis, and antimicrobial defense.
Gene Information Card
| Symbol | CCL28 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 28 |
| Gene Type | protein-coding |
| Chromosomal Location | 5p12 |
| NCBI Gene ID | 56477 ncbi.nlm.nih.gov/gene/56477 |
| Ensembl ID | ENSG00000106144 |
| UniProt ID | Q9NRJ3 |
| OMIM ID | 607616 |
| HGNC ID | 10623 |
| Aliases | SCYA28, MEC, CCK1, SCYA28L, MIP-3-alpha-like |
Description
CCL28 (C-C Motif Chemokine Ligand 28) is a chemokine that binds to receptors CCR10 and CCR3. It is constitutively expressed in mucosal tissues (e.g., colon, salivary gland, mammary gland) and plays a critical role in the homing of IgA-secreting plasma cells and effector T cells to mucosal sites. CCL28 also exhibits antimicrobial activity against bacteria and fungi, and is involved in angiogenesis and tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | CCL28 overexpression promotes tumor angiogenesis and immune evasion via CCR10 signaling. | PMID: 22952446; COSMIC |
| Inflammatory Bowel Disease (IBD) | Elevated CCL28 levels correlate with mucosal inflammation and recruitment of CCR10+ lymphocytes. | PMID: 21199327; ClinVar |
| Asthma | CCL28 expression in airway epithelium attracts CCR3+ eosinophils, contributing to allergic inflammation. | PMID: 15972662 |
| Breast Cancer | CCL28 mediates metastasis to mucosal sites and promotes tumor growth through CCR10. | PMID: 22952446; COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Colon | 24.5 | High |
| Salivary Gland | 18.2 | High |
| Mammary Gland | 12.8 | Medium |
| Trachea | 10.1 | Medium |
| Lung | 6.3 | Low |
| Small Intestine | 15.7 | High |
| Skin | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Caco-2 (colon adenocarcinoma) | 22.1 | High expression |
| MCF-7 (breast adenocarcinoma) | 14.5 | Moderate expression |
| A549 (lung carcinoma) | 8.3 | Low expression |
| HUVEC (endothelial) | 5.6 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Likely loss of start codon; functional impact unknown |
| c.215C>T (p.Thr72Met) | Missense | <0.01% | Rare; no known disease association |
| c.337G>A (p.Gly113Ser) | Missense | <0.01% | Reported in COSMIC; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • extracellular region (GO:0005576) |
| • lymphocyte chemotaxis (GO:0048247) | • angiogenesis (GO:0001525) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• CCR10-mediated signaling (Reactome: R-HSA-373076)
Protein Summary
CCL28 is a 127-amino acid secreted chemokine with a conserved CC motif. It is produced as a precursor with a 20-amino acid signal peptide. The mature protein binds to CCR10 and CCR3, mediating chemotaxis of lymphocytes, eosinophils, and plasma cells. It also possesses antimicrobial activity via a C-terminal cationic domain. CCL28 is implicated in mucosal immunity, angiogenesis, and tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL28 Knockout HEK293 Cell Line | EDJ-KQ12819 | Human | 56477 | Details Get a Quote |
| CCL28 Knockout HeLa Cell Line | EDJ-KQ41953 | Human | 56477 | Details Get a Quote |
| CCL28 Knockout A-549 Cell Line | EDJ-KQ65243 | Human | 56477 | Details Get a Quote |
| CCL28 Knockout HCT 116 Cell Line | EDJ-KQ73683 | Human | 56477 | Details Get a Quote |
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