CCL25: C-C Motif Chemokine Ligand 25
Chemokine involved in thymocyte migration, T-cell development, and intestinal immunity
Gene Information Card
| Symbol | CCL25 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 19p13.2 |
| NCBI Gene ID | 6370 ncbi.nlm.nih.gov/gene/6370 |
| Ensembl ID | ENSG00000131142 |
| UniProt ID | O15444 |
| OMIM ID | 602565 |
| HGNC ID | 10624 |
| Aliases | TECK, SCYA25, Ckb15 |
Description
CCL25 (C-C Motif Chemokine Ligand 25), also known as TECK (Thymus-Expressed Chemokine), is a chemokine that selectively binds to the receptor CCR9. It plays a critical role in the homing of T-cell precursors to the thymus, T-cell development, and the recruitment of lymphocytes to the small intestine. CCL25 is predominantly expressed in the thymus and small intestine, and its dysregulation is implicated in inflammatory bowel disease, colorectal cancer, and autoimmune conditions.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease (IBD) | CCL25/CCR9 axis mediates lymphocyte recruitment to intestinal mucosa, promoting chronic inflammation | PMID: 19124799 |
| Colorectal Cancer | CCL25 overexpression in tumor cells may facilitate immune evasion and metastasis via CCR9 signaling | PMID: 21912597 |
| Thymic Carcinoma | Aberrant CCL25 expression in thymic epithelial tumors may alter T-cell development | PMID: 15601849 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thymus | 12.5 | High |
| Small Intestine | 8.3 | Medium |
| Appendix | 6.1 | Medium |
| Lymph Node | 2.4 | Low |
| Spleen | 1.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| CCRF-CEM (T-cell leukemia) | 15.2 | High expression |
| HCT-116 (colorectal carcinoma) | 9.8 | Moderate expression |
| Jurkat (T-cell lymphoma) | 7.5 | Moderate expression |
| HEK293 (embryonic kidney) | 0.3 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Potential loss of start codon; functional impact unknown |
| c.214C>T (p.Arg72Cys) | Missense | <0.01% | Rare variant; no known disease association |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CCL25.
Gain of Function (GOF)
No gain-of-function mutations reported; overexpression in tumors may mimic gain-of-function.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • CCR9 chemokine receptor binding |
| • inflammatory response | • immune response |
| • positive regulation of T cell migration | • cell-cell signaling |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• T cell receptor signaling pathway (KEGG: hsa04660)
Protein Summary
CCL25 is a 150-amino-acid secreted chemokine containing four conserved cysteine residues characteristic of the CC chemokine family. It is synthesized as a precursor with a 22-amino-acid signal peptide. The mature protein binds specifically to CCR9, a G-protein-coupled receptor, to induce chemotaxis of immature thymocytes, memory T cells, and dendritic cells. CCL25 is essential for T-cell development in the thymus and for gut-specific immune surveillance.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL25 Knockout HEK293 Cell Line | EDJ-KQ1472 | Human | 6370 | Details Get a Quote |
| CCL25 Knockout HeLa Cell Line | EDJ-KQ54431 | Human | 6370 | Details Get a Quote |
| CCL25 Knockout A-549 Cell Line | EDJ-KQ62919 | Human | 6370 | Details Get a Quote |
| CCL25 Knockout HCT 116 Cell Line | EDJ-KQ71388 | Human | 6370 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
