CCL24: C-C Motif Chemokine Ligand 24
A key chemokine in allergic inflammation and eosinophil recruitment
Gene Information Card
| Symbol | CCL24 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 24 |
| Gene Type | protein-coding |
| Chromosomal Location | 7q11.23 |
| NCBI Gene ID | 6369 ncbi.nlm.nih.gov/gene/6369 |
| Ensembl ID | ENSG00000106178 |
| UniProt ID | O00175 |
| OMIM ID | 602495 |
| HGNC ID | 10624 |
| Aliases | Ckb-6, MPIF-2, eotaxin-2, SCYA24 |
Description
CCL24 (C-C Motif Chemokine Ligand 24) encodes a chemokine that belongs to the CC chemokine family. It is also known as eotaxin-2 and MPIF-2. The protein is a potent chemoattractant for eosinophils, basophils, and Th2 lymphocytes, acting through the CCR3 receptor. CCL24 plays a central role in allergic inflammation, asthma, and other eosinophilic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | CCL24 recruits eosinophils via CCR3, contributing to airway inflammation and hyperresponsiveness. | PMID: 10803835; ClinVar |
| Allergic rhinitis | Elevated CCL24 levels in nasal mucosa promote eosinophil infiltration. | PMID: 15005773 |
| Eosinophilic esophagitis | CCL24 overexpression in esophageal tissue drives eosinophil accumulation. | PMID: 17030144 |
| Atopic dermatitis | CCL24 is upregulated in skin lesions, attracting eosinophils and Th2 cells. | PMID: 15379841 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Small intestine | 8.3 | Medium |
| Spleen | 6.1 | Low |
| Thymus | 4.7 | Low |
| Heart | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | High expression after stimulation |
| A549 (lung epithelial) | 3.8 | Low baseline, induced by IL-4 |
| HUVEC (endothelial) | 1.5 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional impact |
| c.208G>A (p.Gly70Ser) | Missense | <0.01% | Reported in ClinVar as benign |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL24.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CCL24.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • CCR3 chemokine receptor binding |
| • extracellular space | • inflammatory response |
| • eosinophil chemotaxis | • cell-cell signaling |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• IL-4 and IL-13 signaling (Reactome: R-HSA-6785807)
Protein Summary
CCL24 is a 119-amino-acid secreted chemokine (8.5 kDa mature form) that binds specifically to CCR3. It is produced by various cell types including monocytes, T cells, and epithelial cells. The protein is structurally characterized by four conserved cysteine residues forming two disulfide bonds. CCL24 is a major mediator of eosinophil trafficking and is implicated in allergic diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL24 Knockout HEK293 Cell Line | EDJ-KQ12818 | Human | 6369 | Details Get a Quote |
| CCL24 Knockout HeLa Cell Line | EDJ-KQ54430 | Human | 6369 | Details Get a Quote |
| CCL24 Knockout A-549 Cell Line | EDJ-KQ62918 | Human | 6369 | Details Get a Quote |
| CCL24 Knockout HCT 116 Cell Line | EDJ-KQ71387 | Human | 6369 | Details Get a Quote |
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