CCL23: Chemokine (C-C Motif) Ligand 23
A key chemokine involved in immune cell recruitment, inflammation, and potential roles in cancer and cardiovascular disease.
Gene Information Card
| Symbol | CCL23 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 23 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 6368 ncbi.nlm.nih.gov/gene/6368 |
| Ensembl ID | ENSG00000108700 |
| UniProt ID | P55773 |
| OMIM ID | 602494 |
| HGNC ID | 10623 |
| Aliases | MPIF-1, CKβ8, MIP-3, SCYA23 |
Description
CCL23 (C-C Motif Chemokine Ligand 23) is a small cytokine belonging to the CC chemokine family. It is primarily produced by monocytes, macrophages, and dendritic cells. CCL23 acts as a chemoattractant for various immune cells, including monocytes, T lymphocytes, and neutrophils, by binding to the chemokine receptor CCR1. It plays a role in inflammatory responses, wound healing, and has been implicated in several diseases, including rheumatoid arthritis, atherosclerosis, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | CCL23 recruits monocytes and T cells to synovial tissue, promoting inflammation and joint destruction. | NCBI Gene, OMIM |
| Atherosclerosis | CCL23 attracts monocytes to arterial walls, contributing to plaque formation. | NCBI Gene, PubMed |
| Cancer (e.g., breast, ovarian) | CCL23 may promote tumor growth and metastasis by recruiting immunosuppressive cells or directly affecting tumor cell migration. | COSMIC, PubMed |
| Inflammatory Bowel Disease | Elevated CCL23 levels in intestinal mucosa correlate with disease activity. | NCBI Gene, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Bone Marrow | 6.1 | Low |
| Lymph Node | 5.4 | Low |
| Liver | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.2 | High expression after LPS stimulation |
| U937 (monocyte) | 10.8 | Moderate expression |
| HUVEC (endothelial) | 2.1 | Low basal expression |
| A549 (lung epithelial) | 1.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Ala34Val) | Missense | <0.01% | Unknown; rare variant in population databases |
| c.205G>A (p.Gly69Ser) | Missense | <0.01% | Unknown; no functional studies reported |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL23.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations described.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • CCR1 chemokine receptor binding |
| • extracellular space | • inflammatory response |
| • chemotaxis | • positive regulation of cell migration |
Pathways
• Cytokine-cytokine receptor interaction
• Chemokine signaling pathway
• Toll-like receptor signaling pathway
Protein Summary
CCL23 is a secreted chemokine of 120 amino acids (mature form 99 aa) with a typical CC chemokine structure. It binds to CCR1 and induces calcium mobilization and chemotaxis in target cells. The protein is involved in immune cell trafficking and inflammatory processes. Post-translational modifications include signal peptide cleavage and disulfide bond formation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL23 Knockout HEK293 Cell Line | EDJ-KQ5732 | Human | 6368 | Details Get a Quote |
| CCL23 Knockout HeLa Cell Line | EDJ-KQ54429 | Human | 6368 | Details Get a Quote |
| CCL23 Knockout A-549 Cell Line | EDJ-KQ62917 | Human | 6368 | Details Get a Quote |
| CCL23 Knockout HCT 116 Cell Line | EDJ-KQ71386 | Human | 6368 | Details Get a Quote |
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