CCL20 Chemokine Ligand 20
CCL20: A key chemokine in inflammation, immune cell trafficking, and cancer progression
Gene Information Card
| Symbol | CCL20 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 20 |
| Gene Type | protein-coding |
| Chromosomal Location | 2q36.3 |
| NCBI Gene ID | 6364 ncbi.nlm.nih.gov/gene/6364 |
| Ensembl ID | ENSG00000115009 |
| UniProt ID | P78556 |
| OMIM ID | 601960 |
| HGNC ID | 10619 |
| Aliases | MIP-3A, LARC, ST38, SCYA20 |
Description
CCL20 (C-C Motif Chemokine Ligand 20) encodes a small cytokine belonging to the CC chemokine family. It is a ligand for the chemokine receptor CCR6 and plays a crucial role in the recruitment of dendritic cells, effector/memory T cells, and B cells to inflammatory sites. CCL20 is involved in mucosal immunity, inflammatory diseases, and cancer progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory Bowel Disease | CCL20 overexpression recruits CCR6+ immune cells to gut mucosa, promoting chronic inflammation | PMID: 20008294 |
| Rheumatoid Arthritis | Elevated CCL20 in synovial fluid attracts Th17 cells via CCR6, driving joint inflammation | PMID: 17982465 |
| Colorectal Cancer | CCL20-CCR6 axis promotes tumor cell proliferation, migration, and metastasis | PMID: 24980573 |
| Psoriasis | Keratinocyte-derived CCL20 recruits CCR6+ T cells to skin lesions | PMID: 17229951 |
| Liver Cancer | CCL20 expression correlates with poor prognosis and immune evasion in hepatocellular carcinoma | PMID: 31451573 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 0.8 | Low |
| Lung | 1.2 | Low |
| Colon | 3.5 | Medium |
| Small Intestine | 4.1 | Medium |
| Lymph Node | 6.2 | High |
| Tonsil | 8.9 | High |
| Appendix | 7.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 0.5 | Low expression |
| HepG2 | 1.1 | Low expression |
| Caco-2 | 4.3 | Moderate expression |
| THP-1 | 6.7 | High expression after LPS stimulation |
| Jurkat | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional impact |
| c.124C>T | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in COSMIC or ClinVar.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • CCR6 chemokine receptor binding |
| • inflammatory response | • immune response |
| • cell chemotaxis | • positive regulation of cell migration |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• IL-17 signaling pathway (KEGG: hsa04657)
Protein Summary
CCL20 is a 96-amino-acid secreted chemokine with a typical CC motif. It binds specifically to CCR6 and induces chemotaxis of immature dendritic cells, memory T cells, and B cells. The protein is involved in homeostatic trafficking to mucosal tissues and is upregulated in inflammatory conditions. Its structure includes four conserved cysteine residues forming disulfide bonds essential for receptor binding.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL20 Knockout HEK293 Cell Line | EDJ-KQ889 | Human | 6364 | Details Get a Quote |
| CCL20 Knockout A-549 Cell Line | EDJ-KQ21060 | Human | 6364 | Details Get a Quote |
| CCL20 Knockout HeLa Cell Line | EDJ-KQ54426 | Human | 6364 | Details Get a Quote |
| CCL20 Knockout HCT 116 Cell Line | EDJ-KQ71383 | Human | 6364 | Details Get a Quote |
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