CCL19: C-C Motif Chemokine Ligand 19
A key chemokine in immune cell trafficking and lymphoid organ development
Gene Information Card
| Symbol | CCL19 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 19 |
| Gene Type | protein-coding |
| Chromosomal Location | 9p13.3 |
| NCBI Gene ID | 6363 ncbi.nlm.nih.gov/gene/6363 |
| Ensembl ID | ENSG00000172724 |
| UniProt ID | Q99731 |
| OMIM ID | 602227 |
| HGNC ID | 10617 |
| Aliases | MIP-3-beta, ELC, exodus-3, SCYA19 |
Description
CCL19 (C-C Motif Chemokine Ligand 19) is a chemokine gene located on chromosome 9p13.3. It encodes a small cytokine belonging to the CC chemokine family. CCL19 is primarily expressed in lymphoid tissues and acts as a ligand for the chemokine receptor CCR7. It plays a critical role in the homing of naive T cells, B cells, and dendritic cells to secondary lymphoid organs, as well as in lymphoid organogenesis and immune surveillance.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rheumatoid Arthritis | CCL19/CCR7 axis promotes recruitment of T cells and dendritic cells to inflamed synovium | PMID: 23300473 |
| HIV Infection | CCL19 can inhibit HIV-1 entry by downregulating CCR5 expression | PMID: 10523647 |
| Cancer Metastasis | CCL19/CCR7 signaling facilitates lymph node metastasis in various cancers | PMID: 15077129 |
| Multiple Sclerosis | Elevated CCL19 levels in CSF correlate with disease activity | PMID: 12867500 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | High |
| Spleen | 8.3 | High |
| Thymus | 6.1 | Medium |
| Bone marrow | 4.2 | Medium |
| Lung | 1.8 | Low |
| Small intestine | 1.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 3.2 | Moderate expression |
| Jurkat (T cell) | 0.8 | Low expression |
| HEK293 (embryonic kidney) | 0.1 | Very low expression |
| HUVEC (endothelial) | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown functional impact |
| c.124C>T | missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CCL19.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• CCR7 signaling in T cell migration (Reactome: R-HSA-373752)
Protein Summary
CCL19 is a 97-amino-acid secreted chemokine (UniProt Q99731) that forms a homodimer. It binds specifically to the G-protein-coupled receptor CCR7, inducing intracellular calcium mobilization and chemotaxis. The protein is essential for the organization of lymphoid tissue and the migration of dendritic cells and lymphocytes. It is also implicated in inflammatory diseases and cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL19 Knockout HEK293 Cell Line | EDJ-KQ548 | Human | 6363 | Details Get a Quote |
| CCL19 Knockout HeLa Cell Line | EDJ-KQ54425 | Human | 6363 | Details Get a Quote |
| CCL19 Knockout A-549 Cell Line | EDJ-KQ62914 | Human | 6363 | Details Get a Quote |
| CCL19 Knockout HCT 116 Cell Line | EDJ-KQ71382 | Human | 6363 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
