CCL18 (C-C Motif Chemokine Ligand 18)
A key chemokine involved in immune regulation, fibrosis, and tumor microenvironment modulation.
Gene Information Card
| Symbol | CCL18 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 18 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 6362 ncbi.nlm.nih.gov/gene/6362 |
| Ensembl ID | ENSG00000275302 |
| UniProt ID | P55774 |
| OMIM ID | 603227 |
| HGNC ID | 10617 |
| Aliases | MIP-4, PARDC, DC-CK1, AMAC-1, SCYA18, DCCK1, CKb7 |
Description
CCL18 (C-C Motif Chemokine Ligand 18) is a chemokine gene located on chromosome 17q12. It encodes a secreted protein that belongs to the CC chemokine family. CCL18 is primarily expressed by antigen-presenting cells such as dendritic cells and macrophages. It plays a role in immune cell trafficking, particularly attracting naive T cells, B cells, and eosinophils. CCL18 is implicated in fibrotic diseases, allergic inflammation, and tumor progression, where it can promote angiogenesis and immune evasion.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pulmonary Fibrosis | CCL18 promotes fibroblast activation and collagen deposition via interaction with unknown receptors. | PMID: 22936354; NCBI GeneRIF |
| Breast Cancer | CCL18 secreted by tumor-associated macrophages enhances cancer cell invasion and metastasis through PITPNM3 receptor. | PMID: 21399633; COSMIC |
| Rheumatoid Arthritis | Elevated CCL18 levels in synovial fluid contribute to chronic inflammation and joint destruction. | PMID: 15542592; OMIM 603227 |
| Asthma | CCL18 attracts eosinophils and Th2 cells, exacerbating airway inflammation. | PMID: 15128701; ClinVar |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Low |
| Lymph Node | 15.1 | Medium |
| Bone Marrow | 6.7 | Low |
| Adipose Tissue | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 22.4 | High expression after PMA differentiation |
| MCF7 (breast cancer) | 3.1 | Low baseline expression |
| A549 (lung cancer) | 5.8 | Moderate expression |
| HUVEC (endothelial) | 1.2 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.01% | Unknown; rare variant in population databases |
| c.67C>T | Synonymous | <0.01% | No known functional effect |
| c.278G>A | Missense (p.Arg93Gln) | <0.01% | Predicted benign by SIFT; not reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL18.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression in tumors is epigenetic.
Dominant Negative (DN)
Not described for CCL18.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
CCL18 is a 89-amino-acid secreted chemokine (UniProt P55774) with a typical CC chemokine structure, including four conserved cysteine residues. It is produced as a precursor with a 20-amino-acid signal peptide. The mature protein forms a monomer and binds to an unknown receptor, though PITPNM3 has been proposed in cancer contexts. CCL18 is involved in chemoattraction of lymphocytes and monocytes, and its overexpression is linked to fibrosis and tumor progression.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL18 Knockout HEK293 Cell Line | EDJ-KQ1090 | Human | 6362 | Details Get a Quote |
| CCL18 Knockout HeLa Cell Line | EDJ-KQ54424 | Human | 6362 | Details Get a Quote |
| CCL18 Knockout A-549 Cell Line | EDJ-KQ62913 | Human | 6362 | Details Get a Quote |
| CCL18 Knockout HCT 116 Cell Line | EDJ-KQ71381 | Human | 6362 | Details Get a Quote |
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