CCL17 (C-C Motif Chemokine Ligand 17)
Chemokine involved in T-cell trafficking and allergic inflammation
Gene Information Card
| Symbol | CCL17 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 17 |
| Gene Type | protein-coding |
| Chromosomal Location | 16q21 |
| NCBI Gene ID | 6361 ncbi.nlm.nih.gov/gene/6361 |
| Ensembl ID | ENSG00000102970 |
| UniProt ID | Q92583 |
| OMIM ID | 601520 |
| HGNC ID | 10622 |
| Aliases | TARC, ABCD-2, SCYA17 |
Description
CCL17 (C-C Motif Chemokine Ligand 17), also known as TARC (Thymus and Activation-Regulated Chemokine), is a chemokine that binds to CCR4 and CCR8 receptors. It plays a key role in chemoattraction of Th2-type T cells, dendritic cells, and eosinophils, and is implicated in allergic inflammation, atopic dermatitis, and certain lymphomas.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Atopic Dermatitis | CCL17 overexpression recruits Th2 cells via CCR4, promoting skin inflammation | PMID: 11714896; ClinVar |
| Hodgkin Lymphoma | CCL17 is highly expressed by Reed-Sternberg cells, contributing to tumor microenvironment | PMID: 10578056; COSMIC |
| Asthma | CCL17 levels correlate with airway eosinophilia and Th2 response | PMID: 11714896; NCBI Gene |
| Mycosis Fungoides | CCL17/CCR4 axis facilitates skin homing of malignant T cells | PMID: 10578056; OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thymus | 12.5 | High |
| Lung | 8.3 | Medium |
| Skin | 6.1 | Medium |
| Lymph Node | 5.4 | Medium |
| Spleen | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.2 | Low endogenous expression |
| Jurkat | 0.1 | T-cell line, low expression |
| THP-1 | 0.3 | Monocytic line, low expression |
| Primary dendritic cells | 15.0 | High expression upon activation |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Unknown functional effect |
| c.199C>T | Synonymous | <0.1% | No protein change |
| c.275G>A | Missense | <0.1% | Potential altered receptor binding |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL17.
Gain of Function (GOF)
Overexpression in Hodgkin lymphoma and atopic dermatitis suggests gain-of-function at transcriptional level.
Dominant Negative (DN)
Not described for CCL17.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • chemokine-mediated signaling pathway (GO:0070098) |
| • extracellular space (GO:0005615) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Th1 and Th2 cell differentiation (KEGG: hsa04658)
Protein Summary
CCL17 is a 94-amino-acid secreted chemokine (8.5 kDa) that forms a homodimer. It binds to CCR4 and CCR8, leading to G-protein-coupled receptor activation, calcium mobilization, and integrin-mediated adhesion. It is a key mediator of Th2-type immune responses and is overexpressed in allergic diseases and certain lymphomas.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL17 Knockout HEK293 Cell Line | EDJ-KQ12144 | Human | 6361 | Details Get a Quote |
| CCL17 Knockout HeLa Cell Line | EDJ-KQ54423 | Human | 6361 | Details Get a Quote |
| CCL17 Knockout A-549 Cell Line | EDJ-KQ62912 | Human | 6361 | Details Get a Quote |
| CCL17 Knockout HCT 116 Cell Line | EDJ-KQ71380 | Human | 6361 | Details Get a Quote |
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