CCL15: Chemokine (C-C Motif) Ligand 15
A chemokine involved in inflammation, immune cell recruitment, and cancer progression
Gene Information Card
| Symbol | CCL15 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 6359 ncbi.nlm.nih.gov/gene/6359 |
| Ensembl ID | ENSG00000275302 |
| UniProt ID | Q16663 |
| OMIM ID | 601393 |
| HGNC ID | 10613 |
| Aliases | MIP-5, MIP-1 delta, SCYA15, NCC-3, LKN-1, MIP-1d |
Description
CCL15 (C-C Motif Chemokine Ligand 15) is a chemokine gene located on chromosome 17q12. It encodes a secreted protein that belongs to the CC chemokine family. CCL15 acts as a chemoattractant for monocytes, T cells, and eosinophils, and signals through the CCR1 receptor. It plays roles in inflammatory responses, immune surveillance, and has been implicated in cancer progression and metastasis.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Colorectal Cancer | CCL15 overexpression promotes tumor growth and metastasis via CCR1 signaling | PMID: 23455478 |
| Rheumatoid Arthritis | Elevated CCL15 levels in synovial fluid contribute to monocyte recruitment and joint inflammation | PMID: 15657133 |
| Asthma | CCL15 induces eosinophil chemotaxis and is upregulated in airway inflammation | PMID: 10653850 |
| Atherosclerosis | CCL15 mediates monocyte adhesion and infiltration into arterial walls | PMID: 12847290 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.3 | Medium |
| Lung | 8.7 | Medium |
| Spleen | 6.5 | Low |
| Bone Marrow | 4.2 | Low |
| Colon | 3.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocytic) | 15.6 | High expression after LPS stimulation |
| HepG2 (hepatocellular) | 9.8 | Constitutive expression |
| A549 (lung epithelial) | 5.4 | Moderate expression |
| MCF-7 (breast cancer) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.214G>A (p.Gly72Arg) | Missense | <0.01% | Unknown functional impact |
| c.301C>T (p.Arg101Cys) | Missense | <0.01% | Potential loss of chemotactic activity |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL15.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in CCL15.
Dominant Negative (DN)
No dominant-negative mutations reported in CCL15.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • immune response (GO:0006955) |
| • chemotaxis (GO:0006935) | • chemokine-mediated signaling pathway (GO:0070098) |
| • extracellular space (GO:0005615) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• CCR1-mediated chemotaxis (Reactome: R-HSA-380108)
Protein Summary
CCL15 is a 113-amino-acid secreted chemokine with a typical CC motif (two adjacent cysteines). It is synthesized as a precursor and cleaved to produce the mature active form. The protein binds specifically to the CCR1 receptor, inducing calcium mobilization and integrin activation. CCL15 is involved in monocyte and eosinophil recruitment, and its dysregulation is associated with inflammatory diseases and cancer.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL15 Knockout HEK293 Cell Line | EDJ-KQ5730 | Human | 6359 | Details Get a Quote |
| CCL15 Knockout HeLa Cell Line | EDJ-KQ54421 | Human | 6359 | Details Get a Quote |
| CCL15 Knockout A-549 Cell Line | EDJ-KQ62910 | Human | 6359 | Details Get a Quote |
| CCL15 Knockout HCT 116 Cell Line | EDJ-KQ71378 | Human | 6359 | Details Get a Quote |
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