CCL14 (C-C Motif Chemokine Ligand 14)
A chemokine involved in immune cell recruitment and inflammation
Gene Information Card
| Symbol | CCL14 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 14 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 6358 ncbi.nlm.nih.gov/gene/6358 |
| Ensembl ID | ENSG00000108771 |
| UniProt ID | Q16627 |
| OMIM ID | 601393 |
| HGNC ID | 10613 |
| Aliases | HCC-1, SCYA14, MCIF, NCC-2, CKB-1 |
Description
CCL14 (C-C Motif Chemokine Ligand 14) encodes a chemokine that belongs to the CC chemokine family. The encoded protein, also known as HCC-1, is constitutively expressed in various tissues and functions as a chemoattractant for monocytes, eosinophils, and T lymphocytes. It binds to CCR1 and CCR5 receptors and plays a role in inflammatory and immune responses. CCL14 is also implicated in HIV-1 infection as a ligand for the CCR5 coreceptor.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| HIV-1 Infection | CCL14 binds to CCR5, a coreceptor for HIV-1 entry; polymorphisms may affect susceptibility | ClinVar, NCBI |
| Inflammatory Diseases | CCL14 mediates monocyte recruitment in chronic inflammation | NCBI, UniProt |
| Cancer | Dysregulated expression in certain tumors; potential role in tumor microenvironment | COSMIC, NCBI |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Liver | 10.2 | Medium |
| Kidney | 8.9 | Medium |
| Spleen | 7.3 | Low |
| Bone Marrow | 6.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 | 15.3 | Monocytic cell line |
| HepG2 | 9.8 | Hepatocellular carcinoma |
| A549 | 7.4 | Lung carcinoma |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown functional impact |
| c.206G>A (p.Arg69His) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • CCR1 chemokine receptor binding |
| • CCR5 chemokine receptor binding | • extracellular space |
| • inflammatory response | • immune response |
| • cell chemotaxis |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• Toll-like receptor signaling pathway (KEGG: hsa04620)
Protein Summary
CCL14 is a 93-amino-acid secreted chemokine (UniProt Q16627) that forms a homodimer. It is synthesized as a precursor with a 19-amino-acid signal peptide. The mature protein binds to CCR1 and CCR5 receptors, inducing calcium mobilization and chemotaxis in target cells. It is constitutively expressed in many tissues and is involved in homeostatic immune surveillance and inflammation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL14 Knockout HEK293 Cell Line | EDJ-KQ5729 | Human | 6358 | Details Get a Quote |
| CCL14 Knockout HeLa Cell Line | EDJ-KQ54420 | Human | 6358 | Details Get a Quote |
| CCL14 Knockout A-549 Cell Line | EDJ-KQ62909 | Human | 6358 | Details Get a Quote |
| CCL14 Knockout HCT 116 Cell Line | EDJ-KQ71377 | Human | 6358 | Details Get a Quote |
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