CCL13 (C-C Motif Chemokine Ligand 13)
A chemokine involved in inflammatory and immune responses, with roles in allergic diseases and cancer.
Gene Information Card
| Symbol | CCL13 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 13 |
| Gene Type | protein-coding |
| Chromosomal Location | 17q11.2 |
| NCBI Gene ID | 6357 ncbi.nlm.nih.gov/gene/6357 |
| Ensembl ID | ENSG00000181374 |
| UniProt ID | Q99616 |
| OMIM ID | 601391 |
| HGNC ID | 10624 |
| Aliases | MCP-4, SCYA13, NCC-1, CKb10 |
Description
CCL13 (C-C Motif Chemokine Ligand 13) is a chemokine gene located on chromosome 17q11.2. It encodes the monocyte chemoattractant protein 4 (MCP-4), which is a small cytokine involved in immunoregulatory and inflammatory processes. CCL13 binds to chemokine receptors such as CCR2, CCR3, and CCR5, and is implicated in allergic diseases, atherosclerosis, and certain cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | CCL13 recruits eosinophils and Th2 cells via CCR3, contributing to airway inflammation. | ClinVar, PMID: 10803835 |
| Allergic rhinitis | Overexpression of CCL13 in nasal mucosa correlates with eosinophil infiltration. | OMIM 601391, PMID: 10469387 |
| Atherosclerosis | CCL13 promotes monocyte recruitment to arterial walls, enhancing plaque formation. | NCBI Gene, PMID: 11733540 |
| Breast cancer | CCL13 expression in tumor microenvironment may influence macrophage polarization and metastasis. | COSMIC, PMID: 25691885 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | Medium |
| Spleen | 8.3 | Medium |
| Lymph node | 6.7 | Low |
| Bone marrow | 4.2 | Low |
| Liver | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.0 | High expression after LPS stimulation |
| A549 (lung epithelial) | 3.5 | Low basal expression |
| HUVEC (endothelial) | 1.2 | Induced by IL-4 |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.01% | Potential loss of start codon; effect unknown |
| c.214C>T (p.Arg72Cys) | missense | <0.01% | May alter receptor binding affinity |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity | • CCR chemokine receptor binding |
| • inflammatory response | • immune response |
| • cell chemotaxis | • signal transduction |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• IL-17 signaling pathway (KEGG: hsa04657)
Protein Summary
The CCL13 protein (MCP-4) is a 98-amino-acid secreted chemokine that belongs to the CC chemokine family. It is produced by various cell types including monocytes, endothelial cells, and epithelial cells. MCP-4 binds to CCR2, CCR3, and CCR5, mediating chemotaxis of monocytes, eosinophils, T lymphocytes, and basophils. It plays a key role in allergic inflammation, atherosclerosis, and tumor-associated immune modulation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL13 Knockout HEK293 Cell Line | EDJ-KQ547 | Human | 6357 | Details Get a Quote |
| CCL13 Knockout HeLa Cell Line | EDJ-KQ54419 | Human | 6357 | Details Get a Quote |
| CCL13 Knockout A-549 Cell Line | EDJ-KQ62908 | Human | 6357 | Details Get a Quote |
| CCL13 Knockout HCT 116 Cell Line | EDJ-KQ71376 | Human | 6357 | Details Get a Quote |
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