CCL11 (C-C Motif Chemokine Ligand 11)
Eosinophil Chemotactic Protein, Key Mediator in Allergic Inflammation and Eosinophil Recruitment
Gene Information Card
| Symbol | CCL11 |
|---|---|
| Full Name | C-C Motif Chemokine Ligand 11 |
| Gene Type | Protein coding |
| Chromosomal Location | 17q12 |
| NCBI Gene ID | 6356 ncbi.nlm.nih.gov/gene/6356 |
| Ensembl ID | ENSG00000172156 |
| UniProt ID | P51671 |
| OMIM ID | 601156 |
| HGNC ID | 10610 |
| Aliases | SCYA11, eotaxin, MGC22534 |
Description
CCL11 (C-C motif chemokine ligand 11), also known as eotaxin, is a small chemokine that specifically recruits eosinophils to sites of allergic inflammation. It binds to the CCR3 receptor on eosinophils, basophils, and Th2 lymphocytes, playing a central role in asthma, atopic dermatitis, and other eosinophilic disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Asthma | CCL11 overexpression recruits eosinophils to airways, causing inflammation and bronchoconstriction | ClinVar, OMIM |
| Atopic dermatitis | Elevated CCL11 in skin lesions promotes eosinophil infiltration and chronic inflammation | NCBI Gene, OMIM |
| Eosinophilic esophagitis | CCL11-mediated eosinophil accumulation in esophageal mucosa | ClinVar, OMIM |
| Allergic rhinitis | CCL11 induces eosinophil chemotaxis in nasal mucosa | NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lung | 12.5 | High |
| Small intestine | 8.3 | Medium |
| Colon | 6.1 | Medium |
| Heart | 2.4 | Low |
| Brain | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| A549 (lung carcinoma) | 15.2 | High expression |
| HUVEC (endothelial) | 9.7 | Moderate expression |
| THP-1 (monocyte) | 3.1 | Low expression |
| HeLa (cervical) | 1.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs17809012 | SNP | 0.15 (global) | Associated with altered CCL11 levels and asthma risk |
| rs16969415 | SNP | 0.08 (European) | Linked to eosinophil count variation |
| c.67G>A | Missense | <0.01 | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in CCL11.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported; overexpression is primarily transcriptional.
Dominant Negative (DN)
Not described for CCL11.
View complete mutation data：
Gene Ontology (GO)
| • chemokine activity (GO:0008009) | • inflammatory response (GO:0006954) |
| • chemotaxis (GO:0006935) | • eosinophil chemotaxis (GO:0048245) |
| • extracellular space (GO:0005615) |
Pathways
• Chemokine signaling pathway (KEGG: hsa04062)
• Cytokine-cytokine receptor interaction (KEGG: hsa04060)
• IL-17 signaling pathway (KEGG: hsa04657)
Protein Summary
CCL11 (eotaxin) is a 97-amino-acid secreted chemokine that binds exclusively to CCR3. It is a potent chemoattractant for eosinophils and is upregulated in allergic inflammation. The protein contains four conserved cysteine residues forming two disulfide bonds characteristic of the CC chemokine family.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCL11 Knockout HEK293 Cell Line | EDJ-KQ3933 | Human | 6356 | Details Get a Quote |
| CCL11 Knockout HeLa Cell Line | EDJ-KQ54418 | Human | 6356 | Details Get a Quote |
| CCL11 Knockout A-549 Cell Line | EDJ-KQ62907 | Human | 6356 | Details Get a Quote |
| CCL11 Knockout HCT 116 Cell Line | EDJ-KQ71375 | Human | 6356 | Details Get a Quote |
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