CCL1 Gene - C-C Motif Chemokine Ligand 1 | Function, Disease & Expression

CCL1 (C-C motif chemokine ligand 1) is a small cytokine belonging to the CC chemokine family. It is primarily produced by activated T cells and monocytes and functions as a chemoattractant for monocytes, natural killer cells, and immature dendritic cells. CCL1 signals through the CCR8 receptor and plays a role in inflammatory responses, immune regulation, and tumor microenvironment modulation.

Tissue Expression

Cell Line Expression

Hotspot Mutations

Mutation functional classification

• Chemokine signaling pathway (KEGG: hsa04062)

• Cytokine-cytokine receptor interaction (KEGG: hsa04060)

• Toll-like receptor signaling pathway (KEGG: hsa04620)

CCL1 is a 96-amino-acid secreted chemokine (mature form 73 residues) with a typical CC motif (two adjacent cysteines). It is produced as a precursor with a 23-amino-acid signal peptide. The protein forms a monomeric structure stabilized by two disulfide bonds. CCL1 specifically binds to the G-protein-coupled receptor CCR8, inducing calcium mobilization and chemotaxis in target cells. It is involved in Th2-type immune responses and has been implicated in allergic diseases and tumor immune evasion.