CCKAR: Cholecystokinin A Receptor
A G protein-coupled receptor for cholecystokinin and gastrin, involved in digestion, satiety, and pancreatic function.
Gene Information Card
| Symbol | CCKAR |
|---|---|
| Full Name | Cholecystokinin A Receptor |
| Gene Type | protein-coding |
| Chromosomal Location | 4p15.2 |
| NCBI Gene ID | 886 ncbi.nlm.nih.gov/gene/886 |
| Ensembl ID | ENSG00000163349 |
| UniProt ID | P32238 |
| OMIM ID | 118444 |
| HGNC ID | 1570 |
| Aliases | CCK1R, CCK-A, CCK1, CCKRA |
Description
The CCKAR gene encodes the cholecystokinin A receptor, a G protein-coupled receptor (GPCR) that binds cholecystokinin (CCK) and gastrin with high affinity. It is primarily expressed in the gastrointestinal tract and central nervous system, mediating gallbladder contraction, pancreatic enzyme secretion, gastric emptying, and satiety signaling. Activation of CCKAR stimulates phospholipase C and intracellular calcium mobilization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Pancreatic cancer | CCKAR overexpression or aberrant signaling may promote tumor growth via mitogenic pathways. | PMID: 12415271 |
| Obesity | CCKAR variants are associated with reduced satiety and increased food intake. | PMID: 19037247 |
| Gallbladder disease | CCKAR dysfunction impairs gallbladder contraction, contributing to gallstone formation. | PMID: 11342582 |
| Pancreatitis | CCKAR-mediated hyperstimulation of pancreatic acinar cells can induce acute pancreatitis. | PMID: 10488082 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Pancreas | 12.5 | Medium |
| Gallbladder | 8.3 | Medium |
| Stomach | 6.1 | Low |
| Small intestine | 4.7 | Low |
| Brain (cortex) | 1.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| AR42J (rat pancreatic acinar) | - | Model for CCKAR signaling |
| PANC-1 | 0.8 | Low expression |
| MIA PaCa-2 | 0.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.104C>T (p.Pro35Leu) | Missense | <0.01% | Reduced receptor activation |
| c.679G>A (p.Val227Met) | Missense | <0.01% | Altered ligand binding |
| c.1138C>T (p.Arg380*) | Nonsense | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and missense mutations impair receptor signaling, leading to reduced gallbladder contraction and satiety.
Gain of Function (GOF)
Not well documented; some variants may increase receptor activity in pancreatic cancer.
Dominant Negative (DN)
Not reported for CCKAR.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • cholecystokinin receptor activity |
| • gastrin receptor activity | • phospholipase C-activating G protein-coupled receptor signaling pathway |
| • positive regulation of cytosolic calcium ion concentration | • digestion |
| • feeding behavior |
Pathways
• Cholecystokinin receptor signaling pathway
• GPCR downstream signaling
• Calcium signaling pathway
Protein Summary
The cholecystokinin A receptor (CCKAR) is a 428-amino acid GPCR with seven transmembrane domains. It is activated by sulfated CCK and gastrin, leading to Gq/11-mediated phospholipase C activation, inositol trisphosphate production, and intracellular calcium release. CCKAR is critical for digestive enzyme secretion, gallbladder contraction, and appetite regulation. Its dysregulation is implicated in pancreatic cancer, obesity, and biliary tract disorders.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCKAR Knockout HEK293 Cell Line | EDJ-KQ1606 | Human | 886 | Details Get a Quote |
| CCKAR Knockout HeLa Cell Line | EDJ-KQ52802 | Human | 886 | Details Get a Quote |
| CCKAR Knockout A-549 Cell Line | EDJ-KQ61273 | Human | 886 | Details Get a Quote |
| CCKAR Knockout HCT 116 Cell Line | EDJ-KQ69768 | Human | 886 | Details Get a Quote |
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