CCDC89: Coiled-Coil Domain Containing 89
A gene encoding a protein of unknown function, belonging to the coiled-coil domain-containing family.
Gene Information Card
| Symbol | CCDC89 |
|---|---|
| Full Name | coiled-coil domain containing 89 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 285600 ncbi.nlm.nih.gov/gene/285600 |
| Ensembl ID | ENSG00000187957 |
| UniProt ID | Q6ZR37 |
| OMIM ID | Not assigned |
| HGNC ID | HGNC:26870 |
| Aliases | FLJ25333, MGC16384 |
Description
CCDC89 (coiled-coil domain containing 89) is a protein-coding gene located on chromosome 11q13.1. The encoded protein contains a coiled-coil domain, but its specific biological function remains largely uncharacterized. Expression data suggest low to moderate levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations | Not established | No evidence in ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 3.2 | Low |
| Brain | 1.5 | Low |
| Lung | 1.1 | Low |
| Liver | 0.8 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 2.1 | Low expression |
| HeLa | 1.8 | Low expression |
| K562 | 1.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • No GO terms assigned |
Pathways
• No pathways assigned
Protein Summary
The CCDC89 protein (UniProt Q6ZR37) is 244 amino acids long and contains a coiled-coil domain. Its function is unknown, and no structural or functional studies have been reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC89 Knockout HEK293 Cell Line | EDJ-KQ8613 | Human | 220388 | Details Get a Quote |
| CCDC89 Knockout HeLa Cell Line | EDJ-KQ59143 | Human | 220388 | Details Get a Quote |
| CCDC89 Knockout A-549 Cell Line | EDJ-KQ67617 | Human | 220388 | Details Get a Quote |
| CCDC89 Knockout HCT 116 Cell Line | EDJ-KQ76003 | Human | 220388 | Details Get a Quote |
