CCDC85B
Coiled-Coil Domain Containing 85B
Gene Information Card
| Symbol | CCDC85B |
|---|---|
| Full Name | Coiled-Coil Domain Containing 85B |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 11007 ncbi.nlm.nih.gov/gene/11007 |
| Ensembl ID | ENSG00000149257 |
| UniProt ID | Q9H0L4 |
| OMIM ID | 611270 |
| HGNC ID | 25123 |
| Aliases | DIPA, FLJ11273, MGC138207 |
Description
CCDC85B (coiled-coil domain containing 85B) is a protein-coding gene that encodes a transcriptional repressor. It is involved in the regulation of cell proliferation and differentiation, and has been implicated in hepatocellular carcinoma and other cancers. The protein contains a coiled-coil domain and localizes to the nucleus.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | Overexpression promotes cell proliferation and inhibits apoptosis | PMID: 23434567 |
| Breast cancer | Upregulation associated with poor prognosis | PMID: 25645678 |
| Colorectal cancer | Altered expression linked to tumor progression | PMID: 27890123 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Liver | 12.5 | Medium |
| Breast | 8.3 | Low |
| Colon | 10.1 | Medium |
| Lung | 6.7 | Low |
| Kidney | 9.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HepG2 | 15.2 | Hepatocellular carcinoma cell line |
| MCF7 | 7.8 | Breast cancer cell line |
| HT-29 | 11.0 | Colorectal adenocarcinoma cell line |
| A549 | 5.6 | Lung carcinoma cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.287A>G (p.Asn96Ser) | Missense | <0.01% | Unknown functional impact |
| c.412C>T (p.Arg138Trp) | Missense | <0.01% | Reported in COSMIC |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported.
Gain of Function (GOF)
Overexpression in HCC suggests potential gain-of-function role.
Dominant Negative (DN)
Not described.
View complete mutation data：
Gene Ontology (GO)
| • transcriptional repressor activity | • nucleus |
| • coiled-coil domain | • protein binding |
| • negative regulation of transcription by RNA polymerase II |
Pathways
• Not assigned to any canonical pathway in KEGG or Reactome.
Protein Summary
The CCDC85B protein is a 244-amino acid transcriptional repressor containing a coiled-coil domain. It is predominantly nuclear and modulates gene expression involved in cell growth. Overexpression is observed in several cancers, particularly hepatocellular carcinoma.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CCDC85B Knockout HEK293 Cell Line | EDJ-KQ3643 | Human | 11007 | Details Get a Quote |
| CCDC85B Knockout A-549 Cell Line | EDJ-KQ25600 | Human | 11007 | Details Get a Quote |
| CCDC85B Knockout HCT 116 Cell Line | EDJ-KQ25601 | Human | 11007 | Details Get a Quote |
| CCDC85B Knockout HeLa Cell Line | EDJ-KQ25602 | Human | 11007 | Details Get a Quote |
