CARD18
Caspase Recruitment Domain Family Member 18
Gene Information Card
| Symbol | CARD18 |
|---|---|
| Full Name | Caspase Recruitment Domain Family Member 18 |
| Gene Type | protein-coding |
| Chromosomal Location | 11q13.4 |
| NCBI Gene ID | 100506334 ncbi.nlm.nih.gov/gene/100506334 |
| Ensembl ID | ENSG00000214595 |
| UniProt ID | P0DMS8 |
| OMIM ID | 615207 |
| HGNC ID | 37242 |
| Aliases | CARD18, CARD-only protein, ICEBERG |
Description
CARD18 (Caspase Recruitment Domain Family Member 18) encodes a protein containing a caspase recruitment domain (CARD) but lacking a catalytic domain. It functions as a negative regulator of inflammation by inhibiting caspase-1 activation and subsequent IL-1β processing. The gene is located on chromosome 11q13.4 and is primarily expressed in immune tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Inflammatory disorders | CARD18 inhibits caspase-1; dysregulation may contribute to excessive inflammation | NCBI Gene, UniProt |
| Autoinflammatory syndromes | Loss of CARD18 function may impair negative regulation of inflammasome activity | OMIM 615207 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 0.3 | Low |
| Lymph node | 0.2 | Low |
| Bone marrow | 0.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 | 0.5 | Monocytic cell line |
| HEK293 | 0.0 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | Not reported | Unknown |
| c.100C>T | Nonsense | Not reported | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense or frameshift mutations predicted to truncate the protein, impairing caspase-1 inhibition.
Gain of Function (GOF)
Not described in literature.
Dominant Negative (DN)
Not described in literature.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • positive regulation of apoptotic process (GO:0043065) |
| • negative regulation of inflammatory response (GO:0050728) |
Pathways
• Inflammasome pathway (Reactome: R-HSA-844456)
• Interleukin-1 processing (KEGG: hsa04621)
Protein Summary
CARD18 is a small protein (approx. 10 kDa) consisting solely of a caspase recruitment domain. It acts as a decoy by binding to caspase-1 via CARD-CARD interactions, preventing caspase-1 oligomerization and activation. This inhibits the cleavage of pro-IL-1β and pro-IL-18, thereby dampening inflammatory responses. The protein is also known as ICEBERG.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CARD18 Knockout HEK293 Cell Line | EDJ-KQ12726 | Human | 59082 | Details Get a Quote |
| CARD18 Knockout HeLa Cell Line | EDJ-KQ56957 | Human | 59082 | Details Get a Quote |
| CARD18 Knockout A-549 Cell Line | EDJ-KQ65463 | Human | 59082 | Details Get a Quote |
| CARD18 Knockout HCT 116 Cell Line | EDJ-KQ73899 | Human | 59082 | Details Get a Quote |
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