CAPG: Capping Actin Protein, Gelsolin Like
A comprehensive overview of the CAPG gene, its function, expression, and associated diseases.
Gene Information Card
| Symbol | CAPG |
|---|---|
| Full Name | Capping Actin Protein, Gelsolin Like |
| Gene Type | Protein coding |
| Chromosomal Location | 2q11.2 |
| NCBI Gene ID | 822 ncbi.nlm.nih.gov/gene/822 |
| Ensembl ID | ENSG00000142453 |
| UniProt ID | P40121 |
| OMIM ID | 153615 |
| HGNC ID | 1473 |
| Aliases | AFCP, MCP, HEL-S-66 |
Description
The CAPG gene encodes a member of the gelsolin/villin family of actin-regulatory proteins. This protein caps the barbed ends of actin filaments, preventing addition or loss of actin monomers, thereby regulating actin filament assembly and disassembly. It is involved in cytoskeletal remodeling, cell motility, and phagocytosis, particularly in macrophages.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | Altered CAPG expression may promote tumor cell migration and invasion through dysregulation of actin dynamics. | PubMed studies; COSMIC |
| Inflammatory diseases | CAPG modulates macrophage function and actin remodeling, potentially influencing chronic inflammation. | PubMed; UniProt |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 28.3 | High |
| Lung | 22.1 | High |
| Spleen | 20.5 | High |
| Liver | 15.8 | Medium |
| Kidney | 12.4 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 35.2 | High expression |
| HeLa (cervical) | 18.7 | Medium expression |
| A549 (lung) | 22.5 | High expression |
| MCF7 (breast) | 14.1 | Medium expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.256G>A (p.Gly86Arg) | Missense | <0.01% | Unknown functional impact |
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in CAPG.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported in CAPG.
Dominant Negative (DN)
No dominant-negative mutations reported for CAPG.
View complete mutation data：
Gene Ontology (GO)
| • actin filament capping | • actin cytoskeleton organization |
| • barbed-end actin filament capping | • cell motility |
| • phagocytosis |
Pathways
• Regulation of actin cytoskeleton (KEGG: hsa04810)
• Fc gamma R-mediated phagocytosis (KEGG: hsa04666)
Protein Summary
CAPG is a 38 kDa protein that belongs to the gelsolin superfamily. It binds to the barbed ends of actin filaments with high affinity, blocking elongation and depolymerization. The protein is calcium-sensitive and is predominantly expressed in macrophages and other motile cells, where it regulates cytoskeletal dynamics essential for cell migration and phagocytosis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CAPG Knockout HEK293 Cell Line | EDJ-KQ2208 | Human | 822 | Details Get a Quote |
| CAPG Knockout A-549 Cell Line | EDJ-KQ22464 | Human | 822 | Details Get a Quote |
| CAPG Knockout HCT 116 Cell Line | EDJ-KQ22465 | Human | 822 | Details Get a Quote |
| CAPG Knockout HeLa Cell Line | EDJ-KQ22466 | Human | 822 | Details Get a Quote |
