CAND1
Cullin-Associated and Neddylation-Dissociated 1
Gene Information Card
| Symbol | CAND1 |
|---|---|
| Full Name | Cullin-Associated and Neddylation-Dissociated 1 |
| Gene Type | Protein-coding |
| Chromosomal Location | 12q14.1 |
| NCBI Gene ID | 55832 ncbi.nlm.nih.gov/gene/55832 |
| Ensembl ID | ENSG00000111530 |
| UniProt ID | Q86VP6 |
| OMIM ID | 607727 |
| HGNC ID | 30688 |
| Aliases | TBPIP, TIP120A, DKFZp434I1116 |
Description
CAND1 (Cullin-Associated and Neddylation-Dissociated 1) encodes a protein that regulates the assembly and activity of cullin-RING ubiquitin ligase (CRL) complexes. It binds to unneddylated cullins, preventing premature substrate recruitment and promoting CRL remodeling. CAND1 is involved in cell cycle control, transcription, and protein degradation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Lung Cancer | CAND1 overexpression may promote tumor growth by dysregulating CRL activity | PMID: 23431171 |
| Hepatocellular Carcinoma | Altered CAND1 expression correlates with poor prognosis and metastasis | PMID: 25636855 |
| Colorectal Cancer | CAND1 mutations and expression changes linked to tumor progression | PMID: 27323851 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 25.3 | High |
| Lymph Node | 18.7 | Medium |
| Brain | 12.1 | Medium |
| Liver | 8.5 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 22.4 | High expression |
| HeLa | 15.6 | Moderate expression |
| A549 | 10.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1234C>T | Missense | 0.02% | p.Pro412Ser; potential loss of function |
| c.567_568del | Frameshift | <0.01% | Truncation; likely loss of function |
| c.890A>G | Missense | 0.05% | p.Asn297Ser; uncertain significance |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein are predicted to impair CAND1 binding to cullins, disrupting CRL regulation.
Gain of Function (GOF)
No well-characterized gain-of-function mutations reported.
Dominant Negative (DN)
Missense mutations in the cullin-binding domain may act as dominant-negative by sequestering cullins without proper regulation.
View complete mutation data：
Gene Ontology (GO)
| • protein binding | • ubiquitin ligase regulator activity |
| • cullin family protein binding | • cytoplasm |
| • nucleus | • regulation of protein ubiquitination |
Pathways
• Cullin-RING ubiquitin ligase regulation
• Ubiquitin-mediated proteolysis
• Cell cycle
Protein Summary
CAND1 is a 1237-amino acid protein that contains a HEAT repeat domain. It binds to cullins (CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5) and dissociates upon neddylation, facilitating CRL complex assembly and disassembly. It is essential for proper cell cycle progression and protein homeostasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CAND1 Knockout HEK293 Cell Line | EDJ-KQ12720 | Human | 55832 | Details Get a Quote |
| CAND1 Knockout A-549 Cell Line | EDJ-KQ41809 | Human | 55832 | Details Get a Quote |
| CAND1 Knockout HCT 116 Cell Line | EDJ-KQ41810 | Human | 55832 | Details Get a Quote |
| CAND1 Knockout HeLa Cell Line | EDJ-KQ41811 | Human | 55832 | Details Get a Quote |
| SCAND1 Knockout HEK293 Cell Line | EDJ-KQ51302 | Human | 51282 | Details Get a Quote |
| SCAND1 Knockout HeLa Cell Line | EDJ-KQ56268 | Human | 51282 | Details Get a Quote |
| SCAND1 Knockout A-549 Cell Line | EDJ-KQ64757 | Human | 51282 | Details Get a Quote |
| SCAND1 Knockout HCT 116 Cell Line | EDJ-KQ73204 | Human | 51282 | Details Get a Quote |
Displaying Records 1 To 8 Of 8 Records
