CAMP (Cathelicidin Antimicrobial Peptide)

Key effector of innate immunity with antimicrobial and immunomodulatory functions

Gene Information Card

Symbol CAMP
Full Name Cathelicidin Antimicrobial Peptide
Gene Type Protein coding
Chromosomal Location 3p21.31
NCBI Gene ID 820 ncbi.nlm.nih.gov/gene/820
Ensembl ID ENSG00000164047
UniProt ID P49913
OMIM ID 600474
HGNC ID 1472
Aliases CAP-18, LL37, FALL-39, CRAMP

Description

The CAMP gene encodes the cathelicidin antimicrobial peptide, which is cleaved to produce the active peptide LL-37. This peptide plays a critical role in innate immunity by directly killing bacteria, fungi, and viruses, and by modulating immune responses through chemotaxis, angiogenesis, and wound healing. CAMP expression is induced by vitamin D and inflammatory signals, and its dysregulation is linked to infectious diseases, inflammatory disorders, and cancer.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
Rosacea Increased CAMP expression leads to LL-37-induced inflammation and vascular changes OMIM 600474, NCBI Gene
Psoriasis Overexpression of LL-37 triggers autoimmune inflammation via DNA/RNA complexes OMIM 600474, NCBI Gene
Atopic dermatitis Reduced CAMP expression impairs antimicrobial defense, increasing infection risk NCBI Gene, ClinVar
Periodontitis Altered CAMP levels contribute to dysbiosis and chronic inflammation NCBI Gene
Colorectal cancer LL-37 promotes tumor growth and angiogenesis in some contexts COSMIC, NCBI Gene

Expression Profile

Tissue Expression
Tissue nTPM level
Bone marrow 12.5 Medium
Lung 8.3 Medium
Skin 6.1 Low
Small intestine 5.4 Low
Spleen 4.2 Low
Cell Line Expression
Cell Line nTPM Notes
HL-60 (leukemia) 15.2 High expression
A549 (lung) 7.8 Medium expression
HaCaT (keratinocyte) 6.5 Medium expression
THP-1 (monocyte) 5.1 Low expression
Data source：Human Protein Atlas（proteinatlas.org）

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
c.1A>G (p.Met1?) Missense <0.01% Loss of start codon, likely loss of function
c.154G>A (p.Gly52Arg) Missense <0.01% Unknown functional impact
c.298C>T (p.Arg100Trp) Missense <0.01% Unknown functional impact
Mutation functional classification

Loss of Function (LOF)

Rare missense variants (e.g., p.Met1?) likely cause loss of antimicrobial peptide production, increasing susceptibility to infections.

Gain of Function (GOF)

Not well documented; overexpression in rosacea and psoriasis suggests gain-of-function effects via increased LL-37.

Dominant Negative (DN)

No known dominant-negative mutations reported.
View complete mutation data：
ClinVar：https://www.clinvar.com/gene/820
COSMIC：https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CAMP

Gene Ontology (GO)

• defense response (GO:0006952) • defense response to bacterium (GO:0042742)
• defense response to fungus (GO:0050832) • defense response to virus (GO:0051607)
• extracellular space (GO:0005615) • extracellular region (GO:0005576)
• innate immune response (GO:0045087) • cell proliferation (GO:0008283)
• angiogenesis (GO:0001525) • chemotaxis (GO:0006935)

Pathways

• Vitamin D receptor pathway
• Toll-like receptor signaling
• Innate immune system (Reactome R-HSA-168249)
• Antimicrobial peptides (Reactome R-HSA-6803157)

Protein Summary

The CAMP gene encodes a 170-amino acid preproprotein (cathelicidin) that is proteolytically cleaved to generate the active 37-amino acid peptide LL-37. LL-37 has broad-spectrum antimicrobial activity, disrupts microbial membranes, and modulates host immune responses by binding to formyl peptide receptor 2 (FPR2) and other receptors. The protein is stored in neutrophil granules and expressed in epithelial cells, and its production is regulated by vitamin D3.

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Related Products

Product name Cat.No. Species Gene ID
CAMP Knockout HEK293 Cell Line EDJ-KQ3751 Human 820 Details Get a Quote
SCAMP1 Knockout HEK293 Cell Line EDJ-KQ3772 Human 9522 Details Get a Quote
SCAMP2 Knockout HEK293 Cell Line EDJ-KQ6245 Human 10066 Details Get a Quote
SCAMP3 Knockout HEK293 Cell Line EDJ-KQ6883 Human 10067 Details Get a Quote
SCAMP4 Knockout HEK293 Cell Line EDJ-KQ7410 Human 113178 Details Get a Quote
SCAMP5 Knockout HEK293 Cell Line EDJ-KQ15182 Human 192683 Details Get a Quote
SCAMP5 Knockout A-549 Cell Line EDJ-KQ47969 Human 192683 Details Get a Quote
SCAMP5 Knockout HCT 116 Cell Line EDJ-KQ47971 Human 192683 Details Get a Quote
SCAMP5 Knockout HeLa Cell Line EDJ-KQ47972 Human 192683 Details Get a Quote
SCAMP1 Knockout HCT 116 Cell Line EDJ-KQ24501 Human 9522 Details Get a Quote
SCAMP1 Knockout A-549 Cell Line EDJ-KQ25862 Human 9522 Details Get a Quote
SCAMP1 Knockout HeLa Cell Line EDJ-KQ25864 Human 9522 Details Get a Quote
SCAMP2 Knockout A-549 Cell Line EDJ-KQ31476 Human 10066 Details Get a Quote
SCAMP2 Knockout HCT 116 Cell Line EDJ-KQ31477 Human 10066 Details Get a Quote
SCAMP2 Knockout HeLa Cell Line EDJ-KQ31478 Human 10066 Details Get a Quote
Displaying Records 1 To 15 Of 25 Records

Reference Databases

NCBI Gene https://www.ncbi.nlm.nih.gov/gene/820
OMIM https://www.omim.org/entry/600474
HGNC https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1472
Ensembl https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000164047
UniProt https://www.uniprot.org/uniprot/P49913
ClinVar https://www.ncbi.nlm.nih.gov/clinvar/?term=CAMP%5Bgene%5D
COSMIC https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CAMP
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