CAMP (Cathelicidin Antimicrobial Peptide)
Key effector of innate immunity with antimicrobial and immunomodulatory functions
Gene Information Card
| Symbol | CAMP |
|---|---|
| Full Name | Cathelicidin Antimicrobial Peptide |
| Gene Type | Protein coding |
| Chromosomal Location | 3p21.31 |
| NCBI Gene ID | 820 ncbi.nlm.nih.gov/gene/820 |
| Ensembl ID | ENSG00000164047 |
| UniProt ID | P49913 |
| OMIM ID | 600474 |
| HGNC ID | 1472 |
| Aliases | CAP-18, LL37, FALL-39, CRAMP |
Description
The CAMP gene encodes the cathelicidin antimicrobial peptide, which is cleaved to produce the active peptide LL-37. This peptide plays a critical role in innate immunity by directly killing bacteria, fungi, and viruses, and by modulating immune responses through chemotaxis, angiogenesis, and wound healing. CAMP expression is induced by vitamin D and inflammatory signals, and its dysregulation is linked to infectious diseases, inflammatory disorders, and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Rosacea | Increased CAMP expression leads to LL-37-induced inflammation and vascular changes | OMIM 600474, NCBI Gene |
| Psoriasis | Overexpression of LL-37 triggers autoimmune inflammation via DNA/RNA complexes | OMIM 600474, NCBI Gene |
| Atopic dermatitis | Reduced CAMP expression impairs antimicrobial defense, increasing infection risk | NCBI Gene, ClinVar |
| Periodontitis | Altered CAMP levels contribute to dysbiosis and chronic inflammation | NCBI Gene |
| Colorectal cancer | LL-37 promotes tumor growth and angiogenesis in some contexts | COSMIC, NCBI Gene |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone marrow | 12.5 | Medium |
| Lung | 8.3 | Medium |
| Skin | 6.1 | Low |
| Small intestine | 5.4 | Low |
| Spleen | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (leukemia) | 15.2 | High expression |
| A549 (lung) | 7.8 | Medium expression |
| HaCaT (keratinocyte) | 6.5 | Medium expression |
| THP-1 (monocyte) | 5.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon, likely loss of function |
| c.154G>A (p.Gly52Arg) | Missense | <0.01% | Unknown functional impact |
| c.298C>T (p.Arg100Trp) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Rare missense variants (e.g., p.Met1?) likely cause loss of antimicrobial peptide production, increasing susceptibility to infections.
Gain of Function (GOF)
Not well documented; overexpression in rosacea and psoriasis suggests gain-of-function effects via increased LL-37.
Dominant Negative (DN)
No known dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Vitamin D receptor pathway
• Toll-like receptor signaling
• Innate immune system (Reactome R-HSA-168249)
• Antimicrobial peptides (Reactome R-HSA-6803157)
Protein Summary
The CAMP gene encodes a 170-amino acid preproprotein (cathelicidin) that is proteolytically cleaved to generate the active 37-amino acid peptide LL-37. LL-37 has broad-spectrum antimicrobial activity, disrupts microbial membranes, and modulates host immune responses by binding to formyl peptide receptor 2 (FPR2) and other receptors. The protein is stored in neutrophil granules and expressed in epithelial cells, and its production is regulated by vitamin D3.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CAMP Knockout HEK293 Cell Line | EDJ-KQ3751 | Human | 820 | Details Get a Quote |
| CAMP Knockout HeLa Cell Line | EDJ-KQ52786 | Human | 820 | Details Get a Quote |
| CAMP Knockout A-549 Cell Line | EDJ-KQ61255 | Human | 820 | Details Get a Quote |
| CAMP Knockout HCT 116 Cell Line | EDJ-KQ69751 | Human | 820 | Details Get a Quote |
