CALML3: Calmodulin-Like 3
A calcium-binding protein with roles in cell signaling and potential implications in cancer
Gene Information Card
| Symbol | CALML3 |
|---|---|
| Full Name | Calmodulin-Like 3 |
| Gene Type | Protein coding |
| Chromosomal Location | 10p15.1 |
| NCBI Gene ID | 808 ncbi.nlm.nih.gov/gene/808 |
| Ensembl ID | ENSG00000120063 |
| UniProt ID | P27482 |
| OMIM ID | 114185 |
| HGNC ID | 1447 |
| Aliases | CLP, CaM-like protein |
Description
CALML3 encodes a member of the calmodulin family of calcium-binding proteins. This protein is structurally similar to calmodulin but has distinct expression patterns and functions. It is involved in calcium-dependent signal transduction, cell cycle regulation, and cytoskeletal organization. CALML3 is expressed in various tissues, with notable levels in the brain and testis, and has been implicated in certain cancers and neurological disorders.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | CALML3 overexpression may promote cell proliferation and migration through calcium signaling pathways. | COSMIC; PMID: 25691885 |
| Prostate cancer | Altered CALML3 expression is associated with tumor progression and poor prognosis. | COSMIC; PMID: 27387371 |
| Schizophrenia | CALML3 variants have been linked to altered calcium signaling in neurons. | ClinVar; PMID: 25056061 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Testis | 8.3 | Medium |
| Heart | 3.1 | Low |
| Liver | 1.2 | Low |
| Kidney | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 (breast cancer) | 15.4 | Overexpressed compared to normal breast tissue |
| PC3 (prostate cancer) | 9.8 | Moderate expression |
| SH-SY5Y (neuroblastoma) | 11.2 | High expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.101C>T (p.Thr34Met) | Missense | <0.01% | Unknown; predicted benign by SIFT |
| c.205G>A (p.Glu69Lys) | Missense | <0.01% | Unknown; predicted possibly damaging by PolyPhen |
| c.316_317insA | Frameshift | <0.01% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift mutations (e.g., c.316_317insA) likely result in truncated protein and loss of calcium-binding ability.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • calcium ion binding (GO:0005509) | • protein binding (GO:0005515) |
| • cytoplasm (GO:0005737) | • plasma membrane (GO:0005886) |
| • intracellular signal transduction (GO:0035556) |
Pathways
• Calcium signaling pathway (KEGG: hsa04020)
• Calmodulin-dependent signaling (Reactome: R-HSA-111997)
Protein Summary
Calmodulin-like 3 (CALML3) is a 148-amino acid protein with four EF-hand calcium-binding domains. It shares 85% sequence identity with calmodulin but has distinct tissue distribution and binding partners. CALML3 modulates calcium-dependent processes such as cell cycle progression, cytoskeletal dynamics, and gene expression. Its overexpression in certain cancers suggests a role in tumorigenesis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CALML3 Knockout HEK293 Cell Line | EDJ-KQ1222 | Human | 810 | Details Get a Quote |
| CALML3 Knockout HeLa Cell Line | EDJ-KQ52783 | Human | 810 | Details Get a Quote |
| CALML3 Knockout A-549 Cell Line | EDJ-KQ61251 | Human | 810 | Details Get a Quote |
| CALML3 Knockout HCT 116 Cell Line | EDJ-KQ69748 | Human | 810 | Details Get a Quote |
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