CALCB: Calcitonin-Related Polypeptide Beta
Gene encoding a neuropeptide involved in pain transmission and vasodilation
Gene Information Card
| Symbol | CALCB |
|---|---|
| Full Name | calcitonin related polypeptide beta |
| Gene Type | protein-coding |
| Chromosomal Location | 11p15.2 |
| NCBI Gene ID | 797 ncbi.nlm.nih.gov/gene/797 |
| Ensembl ID | ENSG00000111057 |
| UniProt ID | P10092 |
| OMIM ID | 114160 |
| HGNC ID | 1438 |
| Aliases | CGRP2, CGRP-II, CALC2 |
Description
CALCB encodes calcitonin-related polypeptide beta, a member of the calcitonin family of peptides. The gene produces a precursor protein that is proteolytically processed to generate the mature neuropeptide CGRP-beta (CGRP-II). CGRP-beta is a potent vasodilator and neuromodulator involved in pain transmission, particularly in migraine pathophysiology. It is expressed primarily in sensory neurons and the central nervous system.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Migraine | CGRP-beta acts as a vasodilator and nociceptive modulator; elevated levels during migraine attacks | ClinVar, OMIM |
| Hypertension | Vasodilatory effects of CGRP-beta may contribute to blood pressure regulation | NCBI Gene, PubMed |
| Osteoarthritis | CGRP-beta involvement in neurogenic inflammation and pain signaling | PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Thyroid | 0.6 | Low |
| Brain | 3.2 | Medium |
| Spinal cord | 5.1 | Medium |
| Testis | 1.8 | Low |
| Lung | 0.3 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y | 2.5 | Neuroblastoma cell line |
| SK-N-SH | 3.0 | Neuroblastoma cell line |
| HEK293 | 0.1 | Low expression |
| A549 | 0.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.214C>T | missense | <0.01% | Unknown |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No confirmed dominant-negative variants reported.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Calcitonin-like ligand receptors (Reactome: R-HSA-420092)
• GPCR ligand binding (Reactome: R-HSA-500792)
• Neuropeptide signaling pathway (KEGG: hsa04728)
Protein Summary
The CALCB protein (UniProt P10092) is a 128-amino acid precursor that is cleaved to produce the mature CGRP-beta peptide (37 amino acids). CGRP-beta contains a disulfide bond between Cys2 and Cys7, forming a ring structure essential for receptor binding. It acts via the calcitonin receptor-like receptor (CALCRL) in complex with receptor activity-modifying proteins (RAMPs), primarily RAMP1. The peptide is a potent vasodilator and plays a key role in nociception, neurogenic inflammation, and migraine.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CALCB Knockout HEK293 Cell Line | EDJ-KQ12714 | Human | 797 | Details Get a Quote |
| CALCB Knockout HeLa Cell Line | EDJ-KQ52780 | Human | 797 | Details Get a Quote |
| CALCB Knockout A-549 Cell Line | EDJ-KQ61248 | Human | 797 | Details Get a Quote |
| CALCB Knockout HCT 116 Cell Line | EDJ-KQ69745 | Human | 797 | Details Get a Quote |
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