CADM4: Cell Adhesion Molecule 4 (Immunoglobulin Superfamily)
A tumor suppressor gene encoding a transmembrane glycoprotein involved in cell-cell adhesion and neuronal development.
Gene Information Card
| Symbol | CADM4 |
|---|---|
| Full Name | Cell Adhesion Molecule 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 19q13.31 |
| NCBI Gene ID | 199731 ncbi.nlm.nih.gov/gene/199731 |
| Ensembl ID | ENSG00000105699 |
| UniProt ID | Q8NFZ8 |
| OMIM ID | 609154 |
| HGNC ID | 30828 |
| Aliases | IGSF4C, NECL4, TSLL2, synCAM4 |
Description
CADM4 (Cell Adhesion Molecule 4) encodes a member of the immunoglobulin superfamily. The protein is a transmembrane glycoprotein that mediates homophilic and heterophilic cell-cell adhesion. It functions as a tumor suppressor in various cancers and plays a role in neuronal development and synaptic organization.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Prostate cancer | Loss of CADM4 expression via promoter methylation leads to reduced cell adhesion and increased metastasis. | PMID: 20628086; COSMIC |
| Breast cancer | Downregulation of CADM4 correlates with poor prognosis and invasive phenotype. | PMID: 22952190; ClinVar |
| Lung cancer | Epigenetic silencing of CADM4 contributes to tumor progression. | PMID: 21573172; COSMIC |
| Colorectal cancer | Reduced CADM4 expression associated with lymph node metastasis. | PMID: 23429708 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Lung | 8.3 | Low |
| Kidney | 6.1 | Low |
| Prostate | 5.4 | Low |
| Breast | 4.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| SH-SY5Y (neuroblastoma) | 15.2 | High expression |
| MCF7 (breast cancer) | 2.1 | Low expression |
| PC3 (prostate cancer) | 1.8 | Low expression |
| A549 (lung cancer) | 3.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163*) | Nonsense | <0.1% | Loss of function; truncated protein |
| c.632G>A (p.Arg211Gln) | Missense | <0.1% | Unknown significance |
| c.1015_1016insA (p.Thr339Asnfs*12) | Frameshift | <0.1% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense and frameshift mutations (e.g., p.Arg163*, p.Thr339Asnfs*12) result in truncated or degraded protein, reducing cell adhesion and tumor suppression.
Gain of Function (GOF)
No gain-of-function mutations reported in CADM4.
Dominant Negative (DN)
No dominant-negative mutations reported in CADM4.
View complete mutation data：
Gene Ontology (GO)
| • cell adhesion (GO:0007155) | • plasma membrane (GO:0005886) |
| • homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156) | • cell junction (GO:0030054) |
| • synapse (GO:0045202) |
Pathways
• Cell adhesion molecules (CAMs) - KEGG hsa04514
• Adherens junction - KEGG hsa04520
Protein Summary
CADM4 is a 442-amino acid transmembrane glycoprotein with an extracellular region containing three immunoglobulin-like domains (V-set and C2-set), a single transmembrane domain, and a cytoplasmic tail with a PDZ-binding motif. It mediates homophilic and heterophilic adhesion with other CADM family members (e.g., CADM1, CADM3). The protein localizes to adherens junctions and synapses, and its loss is associated with epithelial-mesenchymal transition and cancer metastasis.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| CADM4 Knockout HEK293 Cell Line | EDJ-KQ11702 | Human | 199731 | Details Get a Quote |
| CADM4 Knockout HCT 116 Cell Line | EDJ-KQ40040 | Human | 199731 | Details Get a Quote |
| CADM4 Knockout HeLa Cell Line | EDJ-KQ40041 | Human | 199731 | Details Get a Quote |
| CADM4 Knockout A-549 Cell Line | EDJ-KQ67472 | Human | 199731 | Details Get a Quote |
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