C9orf85
Chromosome 9 Open Reading Frame 85
Gene Information Card
| Symbol | C9orf85 |
|---|---|
| Full Name | chromosome 9 open reading frame 85 |
| Gene Type | protein-coding |
| Chromosomal Location | 9q34.3 |
| NCBI Gene ID | 138241 ncbi.nlm.nih.gov/gene/138241 |
| Ensembl ID | ENSG00000188342 |
| UniProt ID | Q5T6F2 |
| OMIM ID | 617020 |
| HGNC ID | 26897 |
| Aliases | MGC16384, bA203J24.7 |
Description
C9orf85 is a protein-coding gene located on chromosome 9q34.3. The encoded protein has no well-characterized function, but it is predicted to be involved in cellular processes based on sequence homology. Expression data suggest low to moderate levels in various tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.0 | Very low |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data
Gain of Function (GOF)
No data
Dominant Negative (DN)
No data
View complete mutation data：
Protein Summary
The C9orf85 protein (UniProt Q5T6F2) is 244 amino acids long with no known domains or functional motifs. Its biological role remains uncharacterized.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C9orf85 Knockout HEK293 Cell Line | EDJ-KQ9408 | Human | 138241 | Details Get a Quote |
| C9orf85 Knockout A-549 Cell Line | EDJ-KQ36062 | Human | 138241 | Details Get a Quote |
| C9orf85 Knockout HCT 116 Cell Line | EDJ-KQ36063 | Human | 138241 | Details Get a Quote |
| C9orf85 Knockout HeLa Cell Line | EDJ-KQ36064 | Human | 138241 | Details Get a Quote |
