C7orf33: A Chromosome 7 Open Reading Frame with Limited Functional Annotation
Explore the genomic context, expression patterns, and current research status of the C7orf33 gene, a protein-coding locus on human chromosome 7.
Gene Information Card
| Symbol | C7orf33 |
|---|---|
| Full Name | chromosome 7 open reading frame 33 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p15.3 |
| NCBI Gene ID | 136895 ncbi.nlm.nih.gov/gene/136895 |
| Ensembl ID | ENSG00000146540 |
| UniProt ID | Q6ZUT6 |
| OMIM ID | Not available |
| HGNC ID | 21400 |
| Aliases | None listed |
Description
C7orf33 (chromosome 7 open reading frame 33) is a protein-coding gene located on the short arm of chromosome 7 at band 7p15.3. The gene spans approximately 12.5 kb and contains multiple exons. The encoded protein has no well-characterized function or domain structure, and its expression is largely uncharacterized. As of current database annotations, C7orf33 is not associated with any known disease, and no pathogenic variants have been reported in ClinVar. The gene is listed in major genomic databases, but functional studies are lacking.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease association | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| No data available | N/A | No expression data from GTEx or HPA |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| No data available | N/A | No expression data from CCLE or other cell line databases |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | N/A | N/A | No variants in COSMIC or ClinVar |
Mutation functional classification
Loss of Function (LOF)
No evidence of loss-of-function mutations or phenotypes.
Gain of Function (GOF)
No evidence of gain-of-function mutations or phenotypes.
Dominant Negative (DN)
No evidence of dominant-negative effects.
View complete mutation data：
Protein Summary
The C7orf33 gene encodes a protein of unknown function. The predicted protein sequence does not contain any characterized domains or motifs. No post-translational modifications or subcellular localization data are available. The protein is not included in any curated protein interaction databases. Further research is needed to elucidate its biological role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C7orf33 Knockout HEK293 Cell Line | EDJ-KQ5354 | Human | 202865 | Details Get a Quote |
| C7orf33 Knockout HeLa Cell Line | EDJ-KQ59037 | Human | 202865 | Details Get a Quote |
| C7orf33 Knockout A-549 Cell Line | EDJ-KQ67516 | Human | 202865 | Details Get a Quote |
| C7orf33 Knockout HCT 116 Cell Line | EDJ-KQ75914 | Human | 202865 | Details Get a Quote |
