C7orf25 Gene
Chromosome 7 Open Reading Frame 25
Gene Information Card
| Symbol | C7orf25 |
|---|---|
| Full Name | chromosome 7 open reading frame 25 |
| Gene Type | protein-coding |
| Chromosomal Location | 7p22.3 |
| NCBI Gene ID | 79048 ncbi.nlm.nih.gov/gene/79048 |
| Ensembl ID | ENSG00000146540 |
| UniProt ID | Q9H2C0 |
| OMIM ID | 617946 |
| HGNC ID | 21710 |
| Aliases | FLJ11273, MGC138290 |
Description
C7orf25 is a protein-coding gene located on chromosome 7p22.3. The encoded protein has no well-characterized function but is predicted to be involved in cellular processes. Expression data suggest ubiquitous low-level transcription. Limited disease associations have been reported.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No established disease association | Unknown | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Liver | 2.8 | Low |
| Kidney | 2.5 | Low |
| Heart | 2.3 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Low expression |
| HeLa | 3.5 | Low expression |
| K562 | 2.9 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | 0.001% (gnomAD) | Unknown functional effect |
Mutation functional classification
Loss of Function (LOF)
No evidence
Gain of Function (GOF)
No evidence
Dominant Negative (DN)
No evidence
View complete mutation data：
Gene Ontology (GO)
| • cellular_component: cytoplasm (GO:0005737) |
Protein Summary
The C7orf25 protein is 145 amino acids long with a predicted molecular weight of 16.5 kDa. No conserved domains or functional motifs have been identified. Subcellular localization is predicted to be cytoplasmic.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C7orf25 Knockout HEK293 Cell Line | EDJ-KQ12635 | Human | 79020 | Details Get a Quote |
| C7orf25 Knockout A-549 Cell Line | EDJ-KQ41700 | Human | 79020 | Details Get a Quote |
| C7orf25 Knockout HCT 116 Cell Line | EDJ-KQ41701 | Human | 79020 | Details Get a Quote |
| C7orf25 Knockout HeLa Cell Line | EDJ-KQ41702 | Human | 79020 | Details Get a Quote |
