C6orf163: A Chromosome 6 Open Reading Frame with Limited Functional Annotation

Explore the genomic context, expression patterns, and current research status of the uncharacterized protein-coding gene C6orf163.

Gene Information Card

Symbol C6orf163
Full Name Chromosome 6 Open Reading Frame 163
Gene Type Protein-coding
Chromosomal Location 6q22.31
NCBI Gene ID 221416 ncbi.nlm.nih.gov/gene/221416
Ensembl ID ENSG00000185008
UniProt ID Q5T0P6
OMIM ID Not available
HGNC ID HGNC:21033
Aliases None reported

Description

C6orf163 is a protein-coding gene located on the long arm of chromosome 6 (6q22.31). The gene encodes a protein of unknown function, and its biological role remains largely uncharacterized. According to NCBI Gene, the gene spans approximately 12 kilobases and contains multiple exons. The protein product is predicted to be localized to the cytoplasm or nucleus, but experimental validation is lacking. C6orf163 is expressed in various tissues, but its physiological significance is not yet understood. No disease associations have been established to date.

Disease Associations

Disease category Pathophysiological mechanism Genomic evidence
No disease associations Not established No evidence from ClinVar, OMIM, or COSMIC

Expression Profile

Tissue Expression
Tissue nTPM level
Testis Not available Low expression
Brain Not available Low expression
Kidney Not available Low expression
Liver Not available Low expression
Cell Line Expression
Cell Line nTPM Notes
HeLa Not available Detected in RNA-seq
HEK293 Not available Detected in RNA-seq
K562 Not available Detected in RNA-seq
Data source:Human Protein Atlas(proteinatlas.org)

Mutations & Variants

Hotspot Mutations
Variant Type Frequency Functional Description
No reported variants Not applicable Not available No functional impact described
Mutation functional classification

Loss of Function (LOF)

No data available

Gain of Function (GOF)

No data available

Dominant Negative (DN)

No data available

Protein Summary

The C6orf163 protein is predicted to be 245 amino acids long with a molecular weight of approximately 27 kDa. It contains no known functional domains, and its structure has not been experimentally determined. The protein sequence is conserved in some mammals, suggesting a possible functional role, but no specific function has been identified. Subcellular localization predictions are inconclusive, and no protein-protein interactions have been reported.

Related Products

Product name Cat.No. Species Gene ID
C6orf163 Knockout HEK293 Cell Line EDJ-KQ6542 Human 206412 Details Get a Quote
C6orf163 Knockout HCT 116 Cell Line EDJ-KQ30720 Human 206412 Details Get a Quote
C6orf163 Knockout HeLa Cell Line EDJ-KQ59060 Human 206412 Details Get a Quote
C6orf163 Knockout A-549 Cell Line EDJ-KQ67537 Human 206412 Details Get a Quote
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