C6orf163: A Chromosome 6 Open Reading Frame with Limited Functional Annotation
Explore the genomic context, expression patterns, and current research status of the uncharacterized protein-coding gene C6orf163.
Gene Information Card
| Symbol | C6orf163 |
|---|---|
| Full Name | Chromosome 6 Open Reading Frame 163 |
| Gene Type | Protein-coding |
| Chromosomal Location | 6q22.31 |
| NCBI Gene ID | 221416 ncbi.nlm.nih.gov/gene/221416 |
| Ensembl ID | ENSG00000185008 |
| UniProt ID | Q5T0P6 |
| OMIM ID | Not available |
| HGNC ID | HGNC:21033 |
| Aliases | None reported |
Description
C6orf163 is a protein-coding gene located on the long arm of chromosome 6 (6q22.31). The gene encodes a protein of unknown function, and its biological role remains largely uncharacterized. According to NCBI Gene, the gene spans approximately 12 kilobases and contains multiple exons. The protein product is predicted to be localized to the cytoplasm or nucleus, but experimental validation is lacking. C6orf163 is expressed in various tissues, but its physiological significance is not yet understood. No disease associations have been established to date.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No disease associations | Not established | No evidence from ClinVar, OMIM, or COSMIC |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | Not available | Low expression |
| Brain | Not available | Low expression |
| Kidney | Not available | Low expression |
| Liver | Not available | Low expression |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | Not available | Detected in RNA-seq |
| HEK293 | Not available | Detected in RNA-seq |
| K562 | Not available | Detected in RNA-seq |
Data source:Human Protein Atlas(proteinatlas.org)
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported variants | Not applicable | Not available | No functional impact described |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data:
Protein Summary
The C6orf163 protein is predicted to be 245 amino acids long with a molecular weight of approximately 27 kDa. It contains no known functional domains, and its structure has not been experimentally determined. The protein sequence is conserved in some mammals, suggesting a possible functional role, but no specific function has been identified. Subcellular localization predictions are inconclusive, and no protein-protein interactions have been reported.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C6orf163 Knockout HEK293 Cell Line | EDJ-KQ6542 | Human | 206412 | Details Get a Quote |
| C6orf163 Knockout HCT 116 Cell Line | EDJ-KQ30720 | Human | 206412 | Details Get a Quote |
| C6orf163 Knockout HeLa Cell Line | EDJ-KQ59060 | Human | 206412 | Details Get a Quote |
| C6orf163 Knockout A-549 Cell Line | EDJ-KQ67537 | Human | 206412 | Details Get a Quote |