C6orf141 Gene - GeneCards | Chromosome 6 Open Reading Frame 141
C6orf141 (chromosome 6 open reading frame 141) is a protein-coding gene located on chromosome 6p12.3. It is also known as MGC46457. The gene is associated with various tissues and may play a role in cellular processes.
Gene Information Card
| Symbol | C6orf141 |
|---|---|
| Full Name | chromosome 6 open reading frame 141 |
| Gene Type | gene with protein product |
| Chromosomal Location | 6p12.3 |
| NCBI Gene ID | 135398 ncbi.nlm.nih.gov/gene/135398 |
| Ensembl ID | ENSG00000197261 |
| UniProt ID | Q5SZD1 |
| OMIM ID | Not available |
| HGNC ID | HGNC:21351 |
| Aliases | MGC46457 |
Description
C6orf141 (chromosome 6 open reading frame 141) is a protein-coding gene located on chromosome 6p12.3. The gene is also known as MGC46457. The protein product is predicted to be involved in various cellular processes, though its exact function is not fully characterized. Expression data indicate that C6orf141 is expressed in multiple tissues, with notable levels in the brain, testis, and kidney. Further research is needed to elucidate its biological roles and potential implications in disease.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Not Available | No specific disease associations have been established for C6orf141. | No evidence from ClinVar or OMIM. |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 8.2 | Low |
| Testis | 6.5 | Low |
| Kidney | 5.1 | Low |
| Liver | 3.4 | Low |
| Heart | 2.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.3 | Moderate expression |
| HeLa | 3.1 | Low expression |
| K562 | 2.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| Not Available | No known mutations | Not available | Not determined |
Mutation functional classification
Loss of Function (LOF)
No data available.
Gain of Function (GOF)
No data available.
Dominant Negative (DN)
No data available.
View complete mutation data：
Protein Summary
The protein encoded by C6orf141 is predicted to be a membrane-associated protein, but its exact function is unknown. It may be involved in cell signaling or transport processes. Further studies are required to determine its physiological role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C6orf141 Knockout HEK293 Cell Line | EDJ-KQ9361 | Human | 135398 | Details Get a Quote |
| C6orf141 Knockout A-549 Cell Line | EDJ-KQ36013 | Human | 135398 | Details Get a Quote |
| C6orf141 Knockout HCT 116 Cell Line | EDJ-KQ36014 | Human | 135398 | Details Get a Quote |
| C6orf141 Knockout HeLa Cell Line | EDJ-KQ36015 | Human | 135398 | Details Get a Quote |
