C6orf136
Chromosome 6 Open Reading Frame 136
Gene Information Card
| Symbol | C6orf136 |
|---|---|
| Full Name | Chromosome 6 Open Reading Frame 136 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 221545 ncbi.nlm.nih.gov/gene/221545 |
| Ensembl ID | ENSG00000196459 |
| UniProt ID | Q5T0J0 |
| OMIM ID | 617089 |
| HGNC ID | HGNC:21270 |
| Aliases | MGC26733, dJ1033B10.2 |
Description
C6orf136 is a protein-coding gene located on chromosome 6p21.1. The encoded protein has no well-characterized function but is predicted to be involved in cellular processes based on sequence homology. Expression data suggest broad but low-level transcription in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease association | Not established | No evidence from ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.3 | Low |
| Brain | 1.8 | Low |
| Lung | 1.2 | Low |
| Liver | 0.9 | Low |
| Kidney | 1.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 1.5 | Low expression |
| HeLa | 1.0 | Low expression |
| K562 | 0.8 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The C6orf136 protein (UniProt Q5T0J0) is 244 amino acids long with no characterized domains or known function. It is predicted to be intracellular but experimental validation is lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C6orf136 Knockout HEK293 Cell Line | EDJ-KQ8851 | Human | 221545 | Details Get a Quote |
| C6orf136 Knockout HeLa Cell Line | EDJ-KQ33926 | Human | 221545 | Details Get a Quote |
| C6orf136 Knockout A-549 Cell Line | EDJ-KQ35165 | Human | 221545 | Details Get a Quote |
| C6orf136 Knockout HCT 116 Cell Line | EDJ-KQ35166 | Human | 221545 | Details Get a Quote |
