C6orf132
Chromosome 6 Open Reading Frame 132
Gene Information Card
| Symbol | C6orf132 |
|---|---|
| Full Name | Chromosome 6 Open Reading Frame 132 |
| Gene Type | Protein-coding |
| Chromosomal Location | 6p21.1 |
| NCBI Gene ID | 221443 ncbi.nlm.nih.gov/gene/221443 |
| Ensembl ID | ENSG00000196187 |
| UniProt ID | Q5T6F2 |
| OMIM ID | 617402 |
| HGNC ID | 21260 |
| Aliases | MGC26733, dJ1033B10.2 |
Description
C6orf132 is a protein-coding gene located on chromosome 6p21.1. The encoded protein has no well-characterized function but is predicted to be involved in cellular processes based on sequence homology. Expression data suggest broad but low-level transcription in multiple tissues.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No established disease associations | Unknown | No direct evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 2.1 | Low |
| Thyroid | 1.8 | Low |
| Adrenal gland | 1.5 | Low |
| Lung | 1.2 | Low |
| Brain | 0.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.5 | Low expression |
| HeLa | 0.3 | Very low |
| K562 | 0.1 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | N/A | N/A | N/A |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Protein Summary
The C6orf132 protein (UniProt Q5T6F2) is 244 amino acids long with no characterized domains or known function. It is predicted to be intracellular but experimental validation is lacking.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C6orf132 Knockout HEK293 Cell Line | EDJ-KQ12632 | Human | 647024 | Details Get a Quote |
| C6orf132 Knockout A-549 Cell Line | EDJ-KQ41695 | Human | 647024 | Details Get a Quote |
| C6orf132 Knockout HCT 116 Cell Line | EDJ-KQ41696 | Human | 647024 | Details Get a Quote |
| C6orf132 Knockout HeLa Cell Line | EDJ-KQ41697 | Human | 647024 | Details Get a Quote |
