C5orf24
Chromosome 5 Open Reading Frame 24
Gene Information Card
| Symbol | C5orf24 |
|---|---|
| Full Name | chromosome 5 open reading frame 24 |
| Gene Type | protein-coding |
| Chromosomal Location | 5q31.1 |
| NCBI Gene ID | 134147 ncbi.nlm.nih.gov/gene/134147 |
| Ensembl ID | ENSG00000164171 |
| UniProt ID | Q8N4H5 |
| OMIM ID | 617461 |
| HGNC ID | 25673 |
| Aliases | MGC10744 |
Description
C5orf24 is a protein-coding gene located on chromosome 5q31.1. The encoded protein has no well-characterized function but is predicted to be involved in cellular processes based on expression data. Limited studies suggest potential roles in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (general) | Altered expression observed in tumor tissues; mechanism unclear | Expression profiling studies (e.g., NCBI GEO) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 15.2 | Medium |
| Thyroid | 10.8 | Medium |
| Lung | 8.5 | Low |
| Brain | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 12.0 | Embryonic kidney cells |
| HeLa | 9.5 | Cervical cancer cells |
| A549 | 7.8 | Lung cancer cells |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | 0.01% (gnomAD) | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function variants reported.
Gain of Function (GOF)
No confirmed gain-of-function variants reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • molecular_function: not yet assigned | • biological_process: not yet assigned |
| • cellular_component: not yet assigned |
Pathways
• No curated pathways available.
Protein Summary
The C5orf24 protein (UniProt Q8N4H5) is 244 amino acids long with no known domains or structural motifs. Its function remains largely uncharacterized, though expression data suggest it may play a role in cell proliferation or differentiation.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C5orf24 Knockout HEK293 Cell Line | EDJ-KQ9346 | Human | 134553 | Details Get a Quote |
| C5orf24 Knockout A-549 Cell Line | EDJ-KQ35984 | Human | 134553 | Details Get a Quote |
| C5orf24 Knockout HCT 116 Cell Line | EDJ-KQ35985 | Human | 134553 | Details Get a Quote |
| C5orf24 Knockout HeLa Cell Line | EDJ-KQ35986 | Human | 134553 | Details Get a Quote |
