C5AR2 (C5a Complement Receptor 2)
A G protein-coupled receptor for complement C5a and C5a-desArg, involved in inflammation and immune regulation.
Gene Information Card
| Symbol | C5AR2 |
|---|---|
| Full Name | complement C5a receptor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 27202 ncbi.nlm.nih.gov/gene/27202 |
| Ensembl ID | ENSG00000134830 |
| UniProt ID | Q9P1Y6 |
| OMIM ID | 615448 |
| HGNC ID | 4527 |
| Aliases | C5L2, GPR77 |
Description
C5AR2 encodes the C5a complement receptor 2, a seven-transmembrane G protein-coupled receptor that binds complement C5a and C5a-desArg. Unlike C5AR1, C5AR2 does not couple to G proteins and may act as a decoy receptor or modulate C5a signaling. It is expressed in various immune cells and tissues, playing roles in inflammation, lipid metabolism, and immune regulation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Sepsis | C5AR2 modulates C5a-mediated inflammatory responses; altered expression may affect sepsis outcome. | PMID: 21788451 |
| Asthma | C5AR2 expression on airway epithelial cells may influence C5a-induced inflammation. | PMID: 24034620 |
| Obesity/Type 2 Diabetes | C5AR2 is involved in adipose tissue inflammation and insulin resistance. | PMID: 23263627 |
| Cancer | C5AR2 expression in tumor microenvironment may modulate immune evasion. | PMID: 25605246 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Adipose tissue | 12.3 | Medium |
| Lung | 8.7 | Low |
| Spleen | 15.2 | Medium |
| Liver | 5.4 | Low |
| Blood | 20.1 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 25.4 | High expression |
| Jurkat (T cell) | 3.2 | Low expression |
| A549 (lung epithelial) | 8.9 | Moderate expression |
| HepG2 (hepatocyte) | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| rs344187 | SNP | 0.05 (5%) | Associated with altered C5AR2 expression in some populations |
| c.698C>T (p.Thr233Ile) | Missense | Rare | Functional impact unknown; may affect receptor stability |
| c.1-18C>T | 5' UTR variant | 0.02 (2%) | Potential effect on translation efficiency |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in ClinVar or COSMIC.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No evidence for dominant-negative effects.
View complete mutation data：
Gene Ontology (GO)
| • G protein-coupled receptor activity | • complement component C5a receptor activity |
| • signal transduction | • inflammatory response |
| • cell surface receptor signaling pathway |
Pathways
• Complement cascade
• GPCR downstream signaling
• Immune system
Protein Summary
C5AR2 is a 337-amino acid protein with seven transmembrane domains. It shares homology with C5AR1 but lacks the DRY motif required for G protein coupling. C5AR2 binds C5a and C5a-desArg with high affinity and may internalize ligands, acting as a scavenger receptor. It is expressed on neutrophils, macrophages, and other cells, and modulates inflammatory responses.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C5AR2 Knockout HEK293 Cell Line | EDJ-KQ2064 | Human | 27202 | Details Get a Quote |
| C5AR2 Knockout HeLa Cell Line | EDJ-KQ22132 | Human | 27202 | Details Get a Quote |
| C5AR2 Knockout A-549 Cell Line | EDJ-KQ64520 | Human | 27202 | Details Get a Quote |
| C5AR2 Knockout HCT 116 Cell Line | EDJ-KQ72978 | Human | 27202 | Details Get a Quote |
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