C5AR1
Complement C5a Receptor 1
Gene Information Card
| Symbol | C5AR1 |
|---|---|
| Full Name | Complement C5a Receptor 1 |
| Gene Type | protein-coding |
| Chromosomal Location | 19q13.32 |
| NCBI Gene ID | 728 ncbi.nlm.nih.gov/gene/728 |
| Ensembl ID | ENSG00000134830 |
| UniProt ID | P21730 |
| OMIM ID | 113995 |
| HGNC ID | 1326 |
| Aliases | C5AR, C5a-R, CD88 |
Description
C5AR1 (Complement C5a Receptor 1) is a protein-coding gene that encodes a G-protein coupled receptor (GPCR) for the complement component C5a. This receptor mediates chemotaxis, degranulation, and superoxide production in neutrophils and other immune cells. It plays a critical role in inflammatory responses, host defense, and is implicated in sepsis, autoimmune diseases, and tumor progression.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Sepsis | C5a-C5AR1 signaling amplifies inflammatory cytokine release and neutrophil activation, contributing to organ failure. | PMID: 25947942 |
| Rheumatoid Arthritis | C5AR1 activation promotes synovial inflammation and joint destruction via leukocyte recruitment. | PMID: 23300472 |
| Cancer (e.g., ovarian, lung) | C5AR1 expression on tumor cells and tumor-associated macrophages supports immune evasion and metastasis. | PMID: 27626308 |
| Age-related Macular Degeneration | C5AR1-mediated inflammation in retinal pigment epithelium contributes to drusen formation and vision loss. | PMID: 23377223 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Bone Marrow | 12.5 | Medium |
| Spleen | 10.8 | Medium |
| Lung | 8.2 | Medium |
| Liver | 3.1 | Low |
| Whole Blood | 15.3 | High |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HL-60 (neutrophil-like) | 18.5 | Differentiated with DMSO |
| THP-1 (monocyte) | 14.2 | After LPS stimulation |
| A549 (lung epithelial) | 2.1 | Basal expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.109C>T (p.Arg37Cys) | Missense | <0.01% | Reduced C5a binding affinity |
| c.631G>A (p.Gly211Arg) | Missense | <0.01% | Impaired receptor internalization |
Mutation functional classification
Loss of Function (LOF)
p.Arg37Cys reduces ligand binding and downstream signaling.
Gain of Function (GOF)
Not reported in C5AR1.
Dominant Negative (DN)
Not reported in C5AR1.
View complete mutation data：
Gene Ontology (GO)
| • G-protein coupled receptor activity | • complement component C5a receptor activity |
| • chemotaxis | • inflammatory response |
| • cell surface receptor signaling pathway |
Pathways
• Complement cascade
• GPCR downstream signaling
• Innate immune system
Protein Summary
C5AR1 is a 350-amino acid transmembrane GPCR with an extracellular N-terminus and seven transmembrane domains. It binds C5a with high affinity, activating Gαi and Gα16 proteins, leading to calcium mobilization, MAPK activation, and chemotaxis. The receptor is expressed predominantly on myeloid cells and is a therapeutic target for inflammatory diseases.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| C5AR1 Knockout HEK293 Cell Line | EDJ-KQ952 | Human | 728 | Details Get a Quote |
| C5AR1 Knockout HCT 116 Cell Line | EDJ-KQ19945 | Human | 728 | Details Get a Quote |
| C5AR1 Knockout HeLa Cell Line | EDJ-KQ19946 | Human | 728 | Details Get a Quote |
| C5AR1 Knockout A-549 Cell Line | EDJ-KQ18615 | Human | 728 | Details Get a Quote |
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