BRS3 (Bombesin Receptor Subtype 3)
G protein-coupled receptor for bombesin-like peptides; implicated in metabolic regulation and cancer
Gene Information Card
| Symbol | BRS3 |
|---|---|
| Full Name | Bombesin Receptor Subtype 3 |
| Gene Type | protein-coding |
| Chromosomal Location | Xq28 |
| NCBI Gene ID | 680 ncbi.nlm.nih.gov/gene/680 |
| Ensembl ID | ENSG00000102239 |
| UniProt ID | P32247 |
| OMIM ID | 300107 |
| HGNC ID | 1120 |
| Aliases | bombesin receptor subtype-3, BB3, GRP-preferring bombesin receptor |
Description
BRS3 encodes a G protein-coupled receptor (GPCR) for bombesin-like peptides. It is primarily expressed in the central nervous system and peripheral tissues, regulating energy homeostasis, glucose metabolism, and thermogenesis. BRS3 is also implicated in cancer cell proliferation and migration.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Obesity | Loss-of-function mutations impair energy expenditure and promote weight gain | PMID: 22991414 |
| Type 2 Diabetes | BRS3 signaling modulates insulin secretion and glucose tolerance | PMID: 25615935 |
| Prostate Cancer | Overexpression activates MAPK/ERK pathway, promoting cell proliferation | PMID: 19137020 |
| Lung Cancer | BRS3 expression correlates with neuroendocrine differentiation | PMID: 10488030 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 0.8 | Low |
| Pancreas | 1.2 | Low |
| Testis | 0.5 | Low |
| Adipose Tissue | 0.3 | Not detected |
| Lung | 0.6 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| NCI-H1299 (Lung) | 0.4 | Neuroendocrine lineage |
| PC-3 (Prostate) | 1.1 | Androgen-independent |
| MCF-7 (Breast) | 0.2 | Low expression |
| HEK293 | 0.1 | Transient expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | Missense | <0.01% | Loss of start codon; predicted loss of function |
| c.374C>T (p.Thr125Met) | Missense | <0.01% | Reduced cell surface expression |
| c.682G>A (p.Gly228Arg) | Missense | <0.01% | Impaired G protein coupling |
Mutation functional classification
Loss of Function (LOF)
Mutations reducing receptor expression or signaling (e.g., p.Thr125Met, p.Gly228Arg) are associated with obesity and metabolic dysfunction.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported in BRS3.
Dominant Negative (DN)
Not described for BRS3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• Bombesin-like peptide signaling (Reactome: R-HSA-375276)
• GPCR downstream signaling (Reactome: R-HSA-388396)
• MAPK signaling (KEGG: hsa04010)
Protein Summary
BRS3 is a 399-amino acid G protein-coupled receptor with seven transmembrane domains. It binds bombesin-like peptides (e.g., GRP, NMB) and activates phospholipase C, leading to intracellular calcium mobilization and MAPK/ERK signaling. The receptor is involved in energy balance, glucose homeostasis, and cancer cell growth.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BRS3 Knockout HEK293 Cell Line | EDJ-KQ4148 | Human | 680 | Details Get a Quote |
| BRS3 Knockout HeLa Cell Line | EDJ-KQ52733 | Human | 680 | Details Get a Quote |
| BRS3 Knockout A-549 Cell Line | EDJ-KQ61205 | Human | 680 | Details Get a Quote |
| BRS3 Knockout HCT 116 Cell Line | EDJ-KQ69698 | Human | 680 | Details Get a Quote |
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