BCL6B
BCL6B Transcription Repressor
Gene Information Card
| Symbol | BCL6B |
|---|---|
| Full Name | BCL6B transcription repressor |
| Gene Type | protein-coding |
| Chromosomal Location | 17p13.1 |
| NCBI Gene ID | 255877 ncbi.nlm.nih.gov/gene/255877 |
| Ensembl ID | ENSG00000161940 |
| UniProt ID | Q8N143 |
| OMIM ID | 608992 |
| HGNC ID | 10019 |
| Aliases | BAZF, ZBTB28, ZNF645 |
Description
BCL6B (BCL6B transcription repressor) is a protein-coding gene located on chromosome 17p13.1. It encodes a zinc finger transcription factor that functions as a transcriptional repressor, similar to BCL6. BCL6B is involved in the regulation of B-cell development and differentiation, and it plays a role in immune responses. The gene is also implicated in certain cancers and developmental processes.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Diffuse large B-cell lymphoma | BCL6B may act as a tumor suppressor; loss of expression contributes to lymphomagenesis | PMID: 15626734 |
| Breast cancer | BCL6B promoter hypermethylation leads to silencing, promoting tumor progression | PMID: 20628033 |
| Gastric cancer | BCL6B downregulation via methylation associated with poor prognosis | PMID: 22198284 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 12.5 | Medium |
| Spleen | 10.2 | Medium |
| Bone marrow | 8.1 | Low |
| Testis | 6.3 | Low |
| Brain | 2.1 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| Raji (Burkitt lymphoma) | 15.4 | High expression |
| K562 (leukemia) | 7.8 | Moderate expression |
| HeLa (cervical cancer) | 3.2 | Low expression |
| MCF7 (breast cancer) | 1.5 | Very low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G (p.Met1?) | missense | <0.1% | Likely loss of start codon; functional impact unknown |
| c.100C>T (p.Arg34Trp) | missense | <0.1% | Unknown significance |
| c.200_201del (p.Glu67fs) | frameshift | <0.1% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations likely lead to truncated protein and loss of repressor activity.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • transcription repressor activity | • DNA-binding transcription factor activity |
| • zinc ion binding | • nucleus |
| • negative regulation of transcription by RNA polymerase II | • B cell differentiation |
Pathways
• BCL6B represses target genes involved in B-cell activation and differentiation
• Potential role in TP53 signaling
Protein Summary
BCL6B is a 561-amino acid zinc finger protein containing a BTB/POZ domain and C2H2 zinc fingers. It functions as a sequence-specific transcriptional repressor, binding to DNA and recruiting corepressor complexes. BCL6B is highly expressed in lymphoid tissues and plays a critical role in germinal center B-cell development. Its expression is frequently silenced by promoter methylation in various cancers, suggesting a tumor suppressor role.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BCL6B Knockout HEK293 Cell Line | EDJ-KQ11054 | Human | 255877 | Details Get a Quote |
| BCL6B Knockout HeLa Cell Line | EDJ-KQ59288 | Human | 255877 | Details Get a Quote |
| BCL6B Knockout A-549 Cell Line | EDJ-KQ67755 | Human | 255877 | Details Get a Quote |
| BCL6B Knockout HCT 116 Cell Line | EDJ-KQ76139 | Human | 255877 | Details Get a Quote |
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