BCL2L15 Gene - BCL2 Like 15
A pro-apoptotic BCL2 family member involved in programmed cell death and cancer
Gene Information Card
| Symbol | BCL2L15 |
|---|---|
| Full Name | BCL2 like 15 |
| Gene Type | protein-coding |
| Chromosomal Location | 1p13.2 |
| NCBI Gene ID | 100130700 ncbi.nlm.nih.gov/gene/100130700 |
| Ensembl ID | ENSG00000204389 |
| UniProt ID | Q5TBC7 |
| OMIM ID | 615679 |
| HGNC ID | 33625 |
| Aliases | Bfk, BCL2L15B |
Description
BCL2L15 (BCL2 like 15) is a protein-coding gene that encodes a pro-apoptotic member of the BCL2 family. The protein contains a BH3 domain and promotes apoptosis by interacting with anti-apoptotic BCL2 family members. It is involved in the regulation of programmed cell death and has been implicated in cancer and other diseases.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | Altered expression of BCL2L15 may contribute to apoptosis evasion in tumor cells | PubMed: 23431136 |
| Colorectal cancer | Downregulation of BCL2L15 associated with poor prognosis | PubMed: 25605247 |
| Lung cancer | BCL2L15 methylation and reduced expression observed | PubMed: 27197149 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Lymph node | 5.2 | Low |
| Spleen | 4.8 | Low |
| Bone marrow | 3.1 | Low |
| Testis | 2.5 | Low |
| Thyroid | 1.9 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 0.8 | Low expression |
| HeLa | 0.5 | Low expression |
| MCF7 | 0.3 | Low expression |
| A549 | 0.2 | Not detected |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | missense | <0.01% | Unknown |
| c.100C>T | nonsense | <0.01% | Predicted loss of function |
Mutation functional classification
Loss of Function (LOF)
Nonsense mutations leading to premature stop codons are predicted to cause loss of function.
Gain of Function (GOF)
No gain-of-function mutations reported.
Dominant Negative (DN)
No dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process (GO:0006915) | • positive regulation of apoptotic process (GO:0043065) |
| • protein binding (GO:0005515) | • identical protein binding (GO:0042802) |
| • cytoplasm (GO:0005737) |
Pathways
• Apoptosis (KEGG: hsa04210)
• p53 signaling pathway (KEGG: hsa04115)
Protein Summary
BCL2L15 encodes a 163-amino acid protein (UniProt Q5TBC7) containing a BH3 domain. It localizes to the cytoplasm and promotes apoptosis by binding and inhibiting anti-apoptotic BCL2 family members such as BCL2 and BCL-XL. The protein is expressed at low levels in lymphoid tissues and is downregulated in several cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BCL2L15 Knockout HEK293 Cell Line | EDJ-KQ12526 | Human | 440603 | Details Get a Quote |
| BCL2L15 Knockout HCT 116 Cell Line | EDJ-KQ41513 | Human | 440603 | Details Get a Quote |
| BCL2L15 Knockout HeLa Cell Line | EDJ-KQ60399 | Human | 440603 | Details Get a Quote |
| BCL2L15 Knockout A-549 Cell Line | EDJ-KQ68867 | Human | 440603 | Details Get a Quote |
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