BATF3
Basic Leucine Zipper ATF-Like Transcription Factor 3
Gene Information Card
| Symbol | BATF3 |
|---|---|
| Full Name | Basic Leucine Zipper ATF-Like Transcription Factor 3 |
| Gene Type | Protein-coding |
| Chromosomal Location | 1q32.3 |
| NCBI Gene ID | 55509 ncbi.nlm.nih.gov/gene/55509 |
| Ensembl ID | ENSG00000123685 |
| UniProt ID | Q9NR55 |
| OMIM ID | 612800 |
| HGNC ID | 958 |
| Aliases | BATF3, BATF-like, JDP1, SNFT |
Description
BATF3 encodes a basic leucine zipper (bZIP) transcription factor belonging to the AP-1/ATF superfamily. It forms heterodimers with JUN family proteins and is essential for the development of CD8α+ dendritic cells and immune homeostasis. BATF3 regulates gene expression in response to immune signals and is implicated in dendritic cell lineage specification.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Immunodeficiency (dendritic cell deficiency) | Loss-of-function mutations impair CD8α+ dendritic cell development | ClinVar, OMIM |
| Colorectal cancer | Altered BATF3 expression may affect anti-tumor immunity | COSMIC, literature |
| Melanoma | BATF3-dependent dendritic cells influence T-cell priming | NCBI, literature |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.8 | Medium |
| Bone marrow | 8.2 | Low |
| Thymus | 7.1 | Low |
| Lung | 3.4 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| K562 | 0.0 | Not expressed |
| HeLa | 0.0 | Not expressed |
| HepG2 | 0.0 | Not expressed |
| Monocytes-derived dendritic cells | 15.2 | High expression |
| CD8+ T cells | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.202C>T (p.Arg68*) | Nonsense | Rare | Loss of function; truncated protein |
| c.347G>A (p.Arg116Gln) | Missense | <0.01% | Unknown significance |
| c.1A>G (p.Met1?) | Start loss | Rare | Loss of function; no translation |
Mutation functional classification
Loss of Function (LOF)
Nonsense and start-loss variants lead to truncated or absent protein, impairing dendritic cell development.
Gain of Function (GOF)
No gain-of-function mutations reported in BATF3.
Dominant Negative (DN)
No dominant-negative mutations reported in BATF3.
View complete mutation data：
Gene Ontology (GO)
Pathways
• AP-1 transcription factor network
• Dendritic cell development pathway
• IL-12 signaling pathway
Protein Summary
BATF3 is a 125-amino acid bZIP transcription factor that heterodimerizes with JUN proteins to regulate gene expression. It is critical for the development of CD8α+ conventional dendritic cells (cDC1s) and plays a role in immune surveillance. The protein localizes to the nucleus and binds to AP-1/ATF DNA response elements.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BATF3 Knockout HEK293 Cell Line | EDJ-KQ12518 | Human | 55509 | Details Get a Quote |
| BATF3 Knockout A-549 Cell Line | EDJ-KQ41501 | Human | 55509 | Details Get a Quote |
| BATF3 Knockout HCT 116 Cell Line | EDJ-KQ41502 | Human | 55509 | Details Get a Quote |
| BATF3 Knockout HeLa Cell Line | EDJ-KQ41503 | Human | 55509 | Details Get a Quote |
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