BATF2: Basic Leucine Zipper ATF-Like Transcription Factor 2
A key regulator of immune response and tumor suppression
Gene Information Card
| Symbol | BATF2 |
|---|---|
| Full Name | Basic Leucine Zipper ATF-Like Transcription Factor 2 |
| Gene Type | Protein coding |
| Chromosomal Location | 11q13.1 |
| NCBI Gene ID | 116071 ncbi.nlm.nih.gov/gene/116071 |
| Ensembl ID | ENSG00000168090 |
| UniProt ID | Q8N1L9 |
| OMIM ID | 615477 |
| HGNC ID | 25182 |
| Aliases | SARI, BATF3, MGC129660 |
Description
BATF2 (Basic Leucine Zipper ATF-Like Transcription Factor 2) is a protein-coding gene that encodes a member of the basic leucine zipper (bZIP) transcription factor family. It functions as a transcriptional repressor and is involved in immune regulation, particularly in dendritic cell and T-cell differentiation. BATF2 also acts as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis in various cancers.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Hepatocellular carcinoma | BATF2 downregulation promotes tumor growth and metastasis via STAT3 signaling | PMID: 21502567 |
| Colorectal cancer | Loss of BATF2 expression correlates with poor prognosis and increased invasion | PMID: 25500545 |
| Gastric cancer | BATF2 suppresses tumorigenesis by inhibiting NF-κB activity | PMID: 26921324 |
| Lung cancer | Reduced BATF2 expression associated with advanced stage and metastasis | PMID: 27323851 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Spleen | 12.5 | Medium |
| Lymph node | 10.2 | Medium |
| Bone marrow | 8.7 | Low |
| Lung | 6.3 | Low |
| Liver | 4.1 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| THP-1 (monocyte) | 15.3 | High expression after LPS stimulation |
| Jurkat (T-cell) | 9.8 | Moderate expression |
| HeLa (cervical cancer) | 2.1 | Low expression |
| HepG2 (liver cancer) | 1.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.247C>T (p.Arg83Trp) | Missense | 0.01% | Unknown effect on function |
| c.421G>A (p.Glu141Lys) | Missense | 0.005% | Potential loss of DNA binding |
| c.568_569del (p.Leu190fs) | Frameshift | 0.002% | Loss of function |
Mutation functional classification
Loss of Function (LOF)
Frameshift and nonsense mutations that truncate the protein, leading to loss of transcriptional repressor activity.
Gain of Function (GOF)
Not reported in literature.
Dominant Negative (DN)
Not reported in literature.
View complete mutation data：
Gene Ontology (GO)
Pathways
• IL-4 signaling pathway
• T-cell receptor signaling pathway
• STAT3 signaling pathway
• NF-κB signaling pathway
Protein Summary
BATF2 is a 286-amino acid protein containing a basic leucine zipper domain that mediates dimerization and DNA binding. It forms heterodimers with JUN family proteins and represses transcription of target genes involved in cell proliferation and immune activation. BATF2 is predominantly expressed in lymphoid tissues and acts as a tumor suppressor in multiple epithelial cancers.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BATF2 Knockout HEK293T Cell Line | EDJ-KQ154 | Human | 116071 | Details Get a Quote |
| BATF2 Knockout HEK293 Cell Line | EDJ-KQ12517 | Human | 116071 | Details Get a Quote |
| BATF2 Knockout HCT 116 Cell Line | EDJ-KQ41500 | Human | 116071 | Details Get a Quote |
| BATF2 Knockout HeLa Cell Line | EDJ-KQ57967 | Human | 116071 | Details Get a Quote |
| BATF2 Knockout A-549 Cell Line | EDJ-KQ66457 | Human | 116071 | Details Get a Quote |
