BANF2
BARF1 Nuclear Assembly Factor 2
Gene Information Card
| Symbol | BANF2 |
|---|---|
| Full Name | BARF1 Nuclear Assembly Factor 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 20p11.23 |
| NCBI Gene ID | 144465 ncbi.nlm.nih.gov/gene/144465 |
| Ensembl ID | ENSG00000125869 |
| UniProt ID | Q8N9N5 |
| OMIM ID | 615079 |
| HGNC ID | 26711 |
| Aliases | FLJ32709, MGC131891 |
Description
BANF2 (BARF1 Nuclear Assembly Factor 2) is a protein-coding gene located on chromosome 20p11.23. It encodes a protein involved in nuclear assembly and chromatin organization. The gene is expressed in various tissues and is associated with cellular processes related to nuclear structure.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations reported | Not applicable | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Lung | 2.8 | Low |
| Liver | 1.5 | Not detected |
| Kidney | 2.0 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK 293 | 4.5 | Moderate expression |
| HeLa | 3.0 | Low expression |
| K562 | 2.1 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No pathogenic variants reported | Not applicable | Not applicable | Not applicable |
Mutation functional classification
Loss of Function (LOF)
No data available
Gain of Function (GOF)
No data available
Dominant Negative (DN)
No data available
View complete mutation data：
Gene Ontology (GO)
| • nuclear assembly | • chromatin binding |
| • nucleus |
Pathways
• Nuclear envelope reassembly
Protein Summary
BANF2 encodes a protein that functions in nuclear assembly and chromatin organization. It is a member of the BANF family and is involved in the reassembly of the nuclear envelope after mitosis. The protein localizes to the nucleus and interacts with chromatin.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BANF2 Knockout HEK293 Cell Line | EDJ-KQ9020 | Human | 140836 | Details Get a Quote |
| BANF2 Knockout HeLa Cell Line | EDJ-KQ58462 | Human | 140836 | Details Get a Quote |
| BANF2 Knockout A-549 Cell Line | EDJ-KQ66949 | Human | 140836 | Details Get a Quote |
| BANF2 Knockout HCT 116 Cell Line | EDJ-KQ75351 | Human | 140836 | Details Get a Quote |
