BAG4 (BCL2-Associated Athanogene 4)
A co-chaperone protein involved in apoptosis regulation and cellular stress response
Gene Information Card
| Symbol | BAG4 |
|---|---|
| Full Name | BCL2-associated athanogene 4 |
| Gene Type | Protein coding |
| Chromosomal Location | 8p11.23 |
| NCBI Gene ID | 9530 ncbi.nlm.nih.gov/gene/9530 |
| Ensembl ID | ENSG00000104419 |
| UniProt ID | O95429 |
| OMIM ID | 603884 |
| HGNC ID | 940 |
| Aliases | SODD, BAG-4 |
Description
BAG4 (BCL2-associated athanogene 4) encodes a member of the BAG family of co-chaperone proteins. The protein contains a BAG domain that interacts with the ATPase domain of Hsp70/Hsc70, modulating chaperone activity. BAG4 also binds to the death domain of tumor necrosis factor receptor 1 (TNFR1) and acts as a silencer of death domain (SODD), thereby inhibiting TNFR1-mediated apoptosis. It is involved in regulating cell survival, proliferation, and stress responses.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Cancer (various types) | BAG4 overexpression may inhibit apoptosis via TNFR1 and Hsp70 pathways, promoting tumor cell survival | COSMIC; literature (PMID: 14525967) |
| Neurodegenerative disorders | Altered BAG4 expression may affect protein quality control and apoptosis in neurons | UniProt; literature (PMID: 19074885) |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 5.2 | Low |
| Heart | 3.8 | Low |
| Liver | 4.1 | Low |
| Lung | 6.0 | Medium |
| Kidney | 4.5 | Low |
| Testis | 7.3 | Medium |
| Spleen | 3.2 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HeLa | 6.5 | Cervical cancer cell line |
| A549 | 5.8 | Lung cancer cell line |
| MCF7 | 4.9 | Breast cancer cell line |
| HEK293 | 7.1 | Embryonic kidney cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.1A>G | Missense | <0.1% | Uncertain significance (ClinVar) |
| c.214C>T | Missense | <0.1% | Uncertain significance (ClinVar) |
| c.487G>A | Missense | <0.1% | Likely benign (ClinVar) |
Mutation functional classification
Loss of Function (LOF)
No well-characterized loss-of-function mutations reported in major databases.
Gain of Function (GOF)
Not established; overexpression studies suggest potential oncogenic role.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • unfolded protein binding (GO:0051082) |
| • Hsp70 protein binding (GO:0030544) | • apoptotic process (GO:0006915) |
| • ubiquitin protein ligase binding (GO:0031625) | • cytosol (GO:0005829) |
| • nucleus (GO:0005634) |
Pathways
• TNF receptor signaling pathway (Reactome: R-HSA-75893)
• Chaperone-mediated autophagy (Reactome: R-HSA-9613829)
• Apoptosis (KEGG: hsa04210)
Protein Summary
BAG4 is a 457-amino acid protein (UniProt O95429) that functions as a co-chaperone for Hsp70/Hsc70 and as a negative regulator of TNFR1 signaling. It contains a conserved BAG domain at the C-terminus and a death domain-binding region. The protein is widely expressed, with highest levels in testis and lung. BAG4 modulates apoptosis, cell survival, and protein homeostasis. Its dysregulation has been implicated in cancer and neurodegenerative conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BAG4 Knockout HEK293 Cell Line | EDJ-KQ1467 | Human | 9530 | Details Get a Quote |
| BAG4 Knockout HCT 116 Cell Line | EDJ-KQ21033 | Human | 9530 | Details Get a Quote |
| BAG4 Knockout HeLa Cell Line | EDJ-KQ21034 | Human | 9530 | Details Get a Quote |
| BAG4 Knockout A-549 Cell Line | EDJ-KQ19698 | Human | 9530 | Details Get a Quote |
