BAG2
BCL2-associated athanogene 2
Gene Information Card
| Symbol | BAG2 |
|---|---|
| Full Name | BCL2-associated athanogene 2 |
| Gene Type | protein-coding |
| Chromosomal Location | 6p12.1 |
| NCBI Gene ID | 9532 ncbi.nlm.nih.gov/gene/9532 |
| Ensembl ID | ENSG00000112208 |
| UniProt ID | O95816 |
| OMIM ID | 603882 |
| HGNC ID | 940 |
| Aliases | BAG-2, dJ417I1.1 |
Description
BAG2 (BCL2-associated athanogene 2) encodes a protein that functions as a co-chaperone, regulating the activity of Hsp70/Hsc70 by modulating nucleotide exchange and substrate release. It plays roles in protein folding, degradation, apoptosis, and cellular stress responses. BAG2 is implicated in neurodegenerative diseases and cancer.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Neurodegenerative disorders (e.g., Alzheimer disease) | BAG2 modulates tau aggregation and clearance via chaperone interactions | PMID: 21832049 |
| Breast cancer | BAG2 overexpression correlates with poor prognosis and chemoresistance | PMID: 25605248 |
| Colorectal cancer | BAG2 promotes cell proliferation and inhibits apoptosis | PMID: 29351290 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 6.1 | Low |
| Kidney | 9.7 | Low |
| Testis | 15.2 | Medium |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 14.0 | High expression |
| HeLa | 11.5 | Moderate expression |
| MCF7 | 9.8 | Moderate expression |
| A549 | 7.2 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.487C>T (p.Arg163Trp) | Missense | <0.01% | Unknown functional impact |
| c.632A>G (p.Asn211Ser) | Missense | <0.01% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
No confirmed loss-of-function mutations reported in major databases.
Gain of Function (GOF)
No confirmed gain-of-function mutations reported.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • adenyl-nucleotide exchange factor activity (GO:0000774) | • Hsp70 protein binding (GO:0030544) |
| • unfolded protein binding (GO:0051082) | • apoptotic process (GO:0006915) |
| • protein folding (GO:0006457) | • cellular response to oxidative stress (GO:0034599) |
Pathways
• Chaperone-mediated autophagy
• Protein processing in endoplasmic reticulum
• Apoptosis modulation by BAG proteins
Protein Summary
BAG2 is a 211-amino acid protein containing a conserved BAG domain at the C-terminus, which binds to the ATPase domain of Hsp70/Hsc70. It acts as a nucleotide exchange factor, promoting substrate release. BAG2 also interacts with BCL2, linking chaperone activity to apoptosis regulation. Its expression is altered in several cancers and neurodegenerative conditions.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BAG2 Knockout HEK293 Cell Line | EDJ-KQ17858 | Human | 9532 | Details Get a Quote |
| BAG2 Knockout A-549 Cell Line | EDJ-KQ24950 | Human | 9532 | Details Get a Quote |
| BAG2 Knockout HeLa Cell Line | EDJ-KQ24951 | Human | 9532 | Details Get a Quote |
| BAG2 Knockout HCT 116 Cell Line | EDJ-KQ23562 | Human | 9532 | Details Get a Quote |
