BAG1
BCL2 Associated Athanogene 1
Gene Information Card
| Symbol | BAG1 |
|---|---|
| Full Name | BCL2 Associated Athanogene 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 9p13.3 |
| NCBI Gene ID | 573 ncbi.nlm.nih.gov/gene/573 |
| Ensembl ID | ENSG00000107262 |
| UniProt ID | Q99933 |
| OMIM ID | 601497 |
| HGNC ID | 937 |
| Aliases | RAP46, HAP, BAG-1 |
Description
BAG1 (BCL2 Associated Athanogene 1) encodes a multifunctional protein that acts as a co-chaperone regulating Hsp70/Hsc70 activity. It modulates apoptosis, cell proliferation, and stress responses by interacting with BCL2, RAF1, and steroid hormone receptors. BAG1 is implicated in cancer, neurodegenerative disorders, and aging.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Breast cancer | BAG1 overexpression inhibits apoptosis via BCL2 interaction, promoting tumor survival | PMID: 10646858 |
| Prostate cancer | BAG1 enhances androgen receptor signaling and therapy resistance | PMID: 15604209 |
| Lung cancer | BAG1 upregulation correlates with poor prognosis and chemoresistance | PMID: 19137073 |
| Alzheimer disease | BAG1 modulates tau aggregation and clearance via Hsp70 | PMID: 23376921 |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Brain | 12.5 | Medium |
| Heart | 8.3 | Low |
| Liver | 15.2 | Medium |
| Lung | 10.1 | Medium |
| Breast | 9.8 | Low |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| MCF7 | 14.5 | Breast cancer cell line |
| A549 | 11.2 | Lung cancer cell line |
| HEK293 | 9.0 | Embryonic kidney |
| HeLa | 13.1 | Cervical cancer cell line |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.647C>T (p.Pro216Leu) | Missense | <0.1% | Altered Hsp70 binding |
| c.1042G>A (p.Glu348Lys) | Missense | <0.1% | Unknown functional impact |
Mutation functional classification
Loss of Function (LOF)
Not well characterized; rare missense variants may impair co-chaperone activity.
Gain of Function (GOF)
Overexpression in cancers leads to enhanced anti-apoptotic signaling.
Dominant Negative (DN)
No confirmed dominant-negative mutations reported.
View complete mutation data：
Gene Ontology (GO)
| • apoptotic process (GO:0006915) | • Hsp70 protein binding (GO:0030544) |
| • unfolded protein binding (GO:0051082) | • nucleus (GO:0005634) |
| • cytoplasm (GO:0005737) |
Pathways
• Apoptosis modulation by BCL2 family
• Chaperone-mediated autophagy
• Estrogen receptor signaling
• RAF/MAPK cascade
Protein Summary
BAG1 is a 345-amino acid protein (UniProt Q99933) containing a conserved BAG domain that binds the ATPase domain of Hsp70/Hsc70. It functions as a nucleotide exchange factor for Hsp70, regulating protein folding, degradation, and stress survival. Isoforms (BAG1S, BAG1M, BAG1L) differ in N-terminal length and subcellular localization.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| BAG1 Knockout HEK293 Cell Line | EDJ-KQ4121 | Human | 573 | Details Get a Quote |
| BAG1 Knockout HCT 116 Cell Line | EDJ-KQ25188 | Human | 573 | Details Get a Quote |
| BAG1 Knockout A-549 Cell Line | EDJ-KQ26521 | Human | 573 | Details Get a Quote |
| BAG1 Knockout HeLa Cell Line | EDJ-KQ26523 | Human | 573 | Details Get a Quote |
