AVPI1 (Arginine Vasopressin Induced 1)
A gene encoding a small protein induced by vasopressin, involved in cellular signaling and potential roles in cancer and renal function.
Gene Information Card
| Symbol | AVPI1 |
|---|---|
| Full Name | Arginine Vasopressin Induced 1 |
| Gene Type | Protein coding |
| Chromosomal Location | 10q24.32 |
| NCBI Gene ID | 60370 ncbi.nlm.nih.gov/gene/60370 |
| Ensembl ID | ENSG00000119950 |
| UniProt ID | Q5VWQ8 |
| OMIM ID | 618121 |
| HGNC ID | 23322 |
| Aliases | FLJ11273, PRO1880 |
Description
AVPI1 (Arginine Vasopressin Induced 1) is a protein-coding gene located on chromosome 10q24.32. The encoded protein is induced by arginine vasopressin (AVP) and is involved in cellular signaling pathways. It has been implicated in renal function and certain cancers, though its precise biological role is still under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| Renal cell carcinoma | Potential role in tumor progression via vasopressin signaling | NCBI Gene, COSMIC |
| Prostate cancer | Overexpression linked to androgen receptor signaling | COSMIC, PubMed |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Kidney | 12.5 | Medium |
| Prostate | 8.3 | Low |
| Testis | 6.1 | Low |
| Liver | 3.2 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 15.0 | High expression |
| HeLa | 7.8 | Moderate expression |
| MCF7 | 4.5 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| c.200G>A (p.Arg67His) | Missense | <0.01% | Unknown functional impact |
| c.115C>T (p.Pro39Ser) | Missense | <0.01% | Reported in COSMIC for renal cancer |
Mutation functional classification
Loss of Function (LOF)
Not established for AVPI1; no confirmed loss-of-function variants reported.
Gain of Function (GOF)
Not established; overexpression in some cancers suggests possible gain-of-function role.
Dominant Negative (DN)
Not reported.
View complete mutation data：
Gene Ontology (GO)
| • protein binding (GO:0005515) | • cytoplasm (GO:0005737) |
| • plasma membrane (GO:0005886) |
Pathways
• Vasopressin-regulated water reabsorption (KEGG: hsa04962)
• Signaling by GPCR (Reactome: R-HSA-372790)
Protein Summary
The AVPI1 protein (UniProt Q5VWQ8) is a small, 147-amino acid protein localized to the cytoplasm and plasma membrane. It is induced by arginine vasopressin and may participate in cellular signaling, particularly in kidney and prostate tissues. Its exact molecular function remains under study, but it is implicated in vasopressin-mediated processes and cancer biology.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| AVPI1 Knockout HEK293 Cell Line | EDJ-KQ12499 | Human | 60370 | Details Get a Quote |
| AVPI1 Knockout A-549 Cell Line | EDJ-KQ40187 | Human | 60370 | Details Get a Quote |
| AVPI1 Knockout HCT 116 Cell Line | EDJ-KQ41476 | Human | 60370 | Details Get a Quote |
| AVPI1 Knockout HeLa Cell Line | EDJ-KQ41477 | Human | 60370 | Details Get a Quote |
Displaying Records 1 To 4 Of 4 Records
