ATP5MGL
ATP Synthase Membrane Subunit G Like
Gene Information Card
| Symbol | ATP5MGL |
|---|---|
| Full Name | ATP Synthase Membrane Subunit G Like |
| Gene Type | protein-coding |
| Chromosomal Location | 1q32.1 |
| NCBI Gene ID | 100287596 ncbi.nlm.nih.gov/gene/100287596 |
| Ensembl ID | ENSG00000203724 |
| UniProt ID | A6NHL2 |
| OMIM ID | - |
| HGNC ID | 37228 |
| Aliases | ATP5MG-like, MGC16384 |
Description
ATP5MGL encodes a protein similar to ATP synthase membrane subunit G, a component of mitochondrial ATP synthase complex. The gene is located on chromosome 1q32.1 and is expressed in various tissues. Its exact functional role in ATP synthesis remains under investigation.
Disease Associations
| Disease category | Pathophysiological mechanism | Genomic evidence |
|---|---|---|
| No specific disease associations | Not established | No evidence in ClinVar or OMIM |
Expression Profile
Tissue Expression
| Tissue | nTPM | level |
|---|---|---|
| Testis | 5.2 | Low |
| Brain | 3.1 | Low |
| Heart | 2.8 | Low |
| Liver | 1.5 | Not detected |
Cell Line Expression
| Cell Line | nTPM | Notes |
|---|---|---|
| HEK293 | 4.0 | Moderate expression |
| HeLa | 3.5 | Moderate expression |
| K562 | 2.0 | Low expression |
Data source：Human Protein Atlas（proteinatlas.org）
Mutations & Variants
Hotspot Mutations
| Variant | Type | Frequency | Functional Description |
|---|---|---|---|
| No reported pathogenic variants | - | - | - |
Mutation functional classification
Loss of Function (LOF)
Not characterized
Gain of Function (GOF)
Not characterized
Dominant Negative (DN)
Not characterized
View complete mutation data：
Gene Ontology (GO)
| • mitochondrial proton-transporting ATP synthase complex | • ATP synthesis coupled proton transport |
Pathways
• Oxidative phosphorylation
• Thermogenesis
Protein Summary
ATP5MGL is a 108-amino acid protein with a single transmembrane domain, predicted to localize to the mitochondrial inner membrane. It shares sequence similarity with ATP5MG, a subunit of the F0 sector of mitochondrial ATP synthase.
Related Services
Related Products
| Product name | Cat.No. | Species | Gene ID | |
|---|---|---|---|---|
| ATP5MGL Knockout HEK293 Cell Line | EDJ-KQ12477 | Human | 267020 | Details Get a Quote |
| ATP5MGL Knockout HeLa Cell Line | EDJ-KQ59360 | Human | 267020 | Details Get a Quote |
| ATP5MGL Knockout A-549 Cell Line | EDJ-KQ67822 | Human | 267020 | Details Get a Quote |
| ATP5MGL Knockout HCT 116 Cell Line | EDJ-KQ76206 | Human | 267020 | Details Get a Quote |
